Associating Liver Partition and Portal vein ligation for Staged hepatectomy (ALPPS) is a novel method to prevent post-hepatectomy hepatic failure. We present a case of periductal infiltrating intrahepatic cholangiocarcinoma undergone ALPPS, that was conducted as intraoperative choice instead of conducting preoperative portal vein embolization (PVE). A 65-year-old male patient was to undergo ext...

Laparoscopic cholecystectomy (LC) and common bile duct exploration (LCBDE) have become the standard surgical procedure for cholecystolithiasis and choledocholithiasis. During the operation, cystic duct and vessels are usually controlled by Hem-o-Lok clips. We report a case with a complaint of severe abdominal pain for the previous 20 days. Her medical history was unremarkable except for laparos...

Farnesoid X receptor (FXR) is a bile acid-activated transcription factor that is a member of the nuclear hormone receptor superfamily. Fxr-null mice exhibit a phenotype similar to Byler disease, an inherited cholestatic liver disorder. In the liver, activation of FXR induces transcription of transporter genes involved in promoting bile acid clearance and represses genes involved in bile acid bi...

Our aim was to investigate whether the antioxidant quercetin protects against liver injury and ameliorates the systemic oxidative stress in rats with common bile duct ligation. Secondary biliary cirrhosis was induced through 28 days of bile duct obstruction. Animals received quercetin (Q) after 14 days of obstruction. Groups of control (CO) and cirrhotic (CBDL) animals received a daily 50 mg/kg...

Thannhauser and Schaber (1) first suggested that the values of the plasma cholesterol esters might be of importance in the diagnosis of hepatic damage in humans. Recently Epstein (2) has demonstrated that parenchymatous disease of the liver in man is associated generally with a marked reduction of the cholesterol esters of the blood. He further found that obstruction of the common bile duct in ...

Bile duct damage is present in virtually all cholangiopathies, which share the biliary epithelial cells (i.e. cholangiocytes) as a common pathogenic target. Cholangiocyte cell death largely occurs through the process of apoptosis. In this review, we will summarize the mechanisms through which biliary damage occurs in a variety of animal and in vitro models, such as extrahepatic cholestasis indu...

Thannhauser and Schaber (1) first suggested that the values of the plasma cholesterol esters might be of importance in the diagnosis of hepatic damage in humans. Recently Epstein (2) has demonstrated that parenchymatous disease of the liver in man is associated generally with a marked reduction of the cholesterol esters of the blood. He further found that obstruction of the common bile duct in ...

abstract autoimmune pancreatitis (aip) is a rare disorder that may be present as common bile duct stricture. the patient was a seventy-year-old man with presentations as recurrent abdominal pain and jaundice, elevated billirobin (bil) and elevated alkaline phosphatase (alkp) in association with the presence of hetrogenesity of the pancreatic head and dilated intra and extra hepatic bile ducts i...

Obstruction of bile flow results in bacterial proliferation and mucosal injury in the small intestine that can lead to the translocation of bacteria across the epithelial barrier and systemic infection. These adverse effects of biliary obstruction can be inhibited by administration of bile acids. Here we show that the farnesoid X receptor (FXR), a nuclear receptor for bile acids, induces genes ...

Objective(s) The liver has major role in the organism homeostasis, interactions with other systems, synthesis and metabolism of bile production, drug detoxification and hormone inactivation. Cholestasis can be defined as an impairment of the bile flow which can lead to hepatocytes necrosis and finally cirrhosis. Some studies reported a gastric acid secretion reduction in cirrhotic subjects, wh...