The synthesis and in vitro anti-HIV activity of a novel series phosphoramidate pronucleotides including S-pivaloyl-2-thioethyl (tBuSATE) group as biolabile phosphate protecting are reported. Such constructs, obtained through different phosphorus chemistries, characterized by the association two nucleoside analogues linked to atom respectively sugar residue exocyclic amino function nucleobase. I...

Articular cartilage is prone to degeneration and possesses extremely poor self-healing capacity due to inherent low cell density and the absence of a vasculature network. Tissue engineered cartilage scaffolds show promise for cartilage repair. However, there still remains a lack of ideal biomimetic tissue scaffolds which effectively stimulate cartilage regeneration with appropriate functional p...

One of the greatest challenges food research is facing in this century lies in maintaining sustainable food production and at the same time delivering high quality food products with an added functionality to prevent life-style related diseases such as, cancer, obesity, diabetes, heart disease, stroke. Functional foods that contain bioactive components may provide desirable health benefits beyo...

Cereal-based products can be used as vehicles for the delivery of relevant bioactive compounds since they are staple foods for most cultures throughout the world. The health promoting benefits of flavonoids and saponins contained in black bean seed coats have been previously described. In the present work, the effect of adding flavonoids and saponins from black bean seed coat to the typical yea...