The development of bioactive glass-ceramic materials has been a topic of great interest aiming at enhancing the mechanical strength of traditional bioactive scaffolds. In the present study, we test and demonstrate the use of Biosilicate® glass-ceramic powder to fabricate bone scaffolds by the foam replica method. Scaffolds possessing the main requirements for use in bone tissue engineering (95%...

This research has been done to study characteristic and biocompatible evaluation of a nano-biocompositeceramic with the bioglass (BG) as a first phase. In this regard, synthesis of S53P4 (53% SiO2, 4% P2O5,23% Na2O and 20% CaO) bioglass has been considered as the first phase and flourapatite (FA) consideredas the second phase. Afterwards, nanocomposite with the base of S53P4 b...

In this work we synthesized mesoporous bioactive glass nanospheres (nMBG) with the aim to utilize them as substrates for loading one of the most potent amino-bisphosphonates, alendronate (AL). The results of the chemical and structural characterization show that the nMBG display a relatively high surface area (528 m²/g) and a mean pore volume of 0.63 cm³/g, both of which decrease on increasing ...

In this work, two bioactive glass powders (SBA2 and SBA3) were doped with Cu by means of the ion-exchange technique in aqueous solution. SBA2 glass was subjected to the ion-exchange process by using different Cu salts (copper(II) nitrate, chloride, acetate, and sulphate) and concentrations. Structural (X-ray diffraction-XRD), morphological (Scanning Electron Microscopy-SEM), and compositional (...

BACKGROUND Iliac crest autograft is currently the gold standard material for spinal fusion. However, its use is limited by additional operative time, increased blood loss, and morbidity. Recently, a synthetic osteoconductive bone graft material composed of bioactive glass has been described, with high effectiveness in animal models. Its ability to achieve spinal fusion in human has never been r...

For a biomaterial to be considered suitable for bone repair it should ideally be both bioactive and have a capacity for controllable drug delivery; as such, mesoporous SiO(2) glass has been proposed as a new class of bone regeneration material by virtue of its high drug-loading ability and generally good biocompatibility. It does, however, have less than optimum bioactivity and controllable dru...

As also observed for conventional silicate glasses, water can be incorporated in the bulk interstitial regions of a bioactive glass (BG) matrix during the glass preparation and/or upon exposure to an aqueous environment. However, in the case of BGs, very little is known about the effect of hydration on the bulk structure, and then on key properties of these materials, such as biodegradation and...