Tanshinone IIA serves as a coenzyme for certain biochemical reactions, exhibiting various pharmacological effects in the treatment of neurological diseases including spinal cord injury (SCI), however, its working mechanism SCI is not clear. Based on previous research, we believe that tanshinone promotes survival and repair nerves after through such anti-inflammatory, antioxidant, prevention cel...

Each of the major classes of clinically useful antibiotics can cause neph­ rotoxicity. Major differences exist among classes, and these are reviewed with regard to the frequency of occurrence of nephrotoxicity, the direct or indirect toxic effects of the drugs, their site(s) of action within the kidney, current views of their pathophysiological effects and observations which provide clues to th...

The association between HLA-B27 and the group of autoimmune inflammatory arthritic diseases, the spondyloarthropathies (SpAs) which include ankylosing spondylitis (AS) and Reactive Arthritis (ReA), has been well established and remains the strongest association between any HLA molecule and autoimmune disease. The mechanism behind this striking association remains elusive; however animal model a...

objective(s) several studies have reported improved response of exercised hearts to myocardial infarction (mi). this study was aimed to evaluate the preventive role of treadmill exercise and diosgenin on cardiac marker enzymes, thiobarbituric acid reactive substances (tbars), total antioxidant status (tas), lipids, and electrocardiographic (ecg) patterns in isoproterenol (iso)-induced myocardia...

teucrium polium can reduce serum glucose. there are few reports in the literature related to this subject and the resolution of this mechanism requires further experiments. the aim of the present study was to evaluate the effects of teucrium polium aerial parts extracts on oral glucose tolerance tests and pancreas histology in streptozocin-induced diabetic rats. in order to prepare the aqueous ...

drought stress is one of the major causes of reduction in crop production. study physiological and biochemical processes related to drought stress can give better insight about mechanism of drought tolerance. to study the physiological and biochemical processes, three genotypes including k-s-31167, ge-288 and naz were subjected to 3 level of drought stress based on 25, 50 and 100 percent of fie...

introduction: the neuroprotective role of opioid morphine against 6-hydroxydopamineinduced cell death has been demonstrated. however, the exact mechanism(s) underlying such neuroprotection, especially the role of subtype receptors, has not yet been fully clarified. methods: here, we investigated the effects of different opioid agonists on 6-ohda-induced neurotoxicity in human neuroblastoma sh-s...

the aim of the current study is to evaluate the potential mechanism of antidiabetic action of the essential oil of artemisia sieberi and its effects on some hematological and biochemical parameters in alloxan induced diabetic rats. extraction of the essential oil from aerial parts of a. sieberi was preformed by hydrodistillation. fifty rats were divided into five groups. groups i and ii normal ...

The effect of high pressure treatment on biochemical changes during storage was investigated using Brassica rapa root. High pressure treated samples with 400 and 600 MPa formed unique green-blue color during 7-d storage at 4 degrees C. The mechanism of green-blue compound formation would be based on biochemical pathway for a unique green-blue pigment synthesis, containing O2-dependent steps and...

antibiotic resistance is a phenomenon in which antibiotic used to treat bacteria becomes useless due to resistance mechanism. increased drug resistance and occurrence of multiple drug resistance in bacteria specificity nosocomial and urinary tract infection bacteria has reduced the possibilities of treating these infectious diseases. efflux pumps are one of the major mechanism of mdr in bacteri...