The concerns about the possible risk of manufactured nanoparticles (NPs) have been raised recently. Nano- and micro-sized copper oxide (CO and CONP) are widely used in many industries. In this regard, in-vitro studies have demonstrated that CONP is a toxic compound in different cell lines. Despite their unique properties, NPs possess unexpected toxicity profiling relative to the bulk m...

OBJECTIVE Non-linear relations between multiple biochemical parameters are the basis for the diagnosis of many diseases. Traditional linear analytical methods are not reliable predictors. Novel nonlinear techniques are increasingly used to improve the diagnostic accuracy of automated data interpretation. This has been exemplified in particular for the classification and diagnostic prediction of...

Objective(s): The purpose of this study was to conduct a meta-analysis on human microRNAs (miRNAs) expression data of endometriosis tissue profiles versus those of normal controls and to identify novel putative diagnostic markers. Materials andMethods: PubMed, Embase, Web of Science, Ovid Medline were used to search for endometriosis miRNA expression profiling studies of endometriosis. The miRN...

Abstract Glucosylceramides are a class of membrane lipids that serve as vital structural and signaling molecules in eukaryotes. In this study, we explored the function Foc GCS, glucosylceramide synthase (GCS) Fusarium oxysporum f. sp. cubense tropical race 4 ( TR4) causes wilt banana plants. FocGCS is highly expressed germinating conidia during early infection stage TR4. Disruption resulted sev...

A fundamental goal of proteomics is to assign physiological functions to all proteins encoded by eukaryotic and prokaryotic genomes. Of the many activities performed by proteins, the chemical transformations catalyzed by enzymes form the basis for most, if not all, metabolic and signaling pathways. Elucidation of these pathways and their integration into larger cellular networks require new str...

We present the coupling of atomic force microscopy (AFM) and nuclear magnetic resonance (NMR) technologies to enable topographical, mechanical, and chemical profiling of biological samples. Here, we fabricate and perform proof-of-concept testing of radiofrequency planar microcoils on commercial AFM cantilevers. The sensitive region of the coil was estimated to cover an approximate volume of 19....

Abstract The ray series method may be generalized using a ray centered coordinate system for general 3D-heterogeneous media. This method is useful for Amplitude Versus Offset (AVO) seismic modeling, seismic analysis, interpretational purposes, and comparison with seismic field observations.For each central ray (constant ray parameter), the kinematic (the eikonal) and dynamic ray tracing system ...

The caspase cascade in Drosophila is controlled primarily by DIAP1 (Drosophila inhibitor of apoptosis), which exerts its regulatory effect by targeting the initiator caspase DRONC for proteasomal degradation. Pro­apoptotic signaling stimulates auto­ubiquitination by DIAP1 and frees DRONC to activate the caspase cascade. We used RT­PCR for expression profiling of Drosophila S2 cells and determin...

With the proteasome emerging as a therapeutic target for cancer treatment, accurate tools for monitoring proteasome (inhibitor) activity are in demand. In this chapter, we describe the synthesis and use of a fluorescent proteasome activity probe that allows for accurate profiling of proteasomal activity in cell lysates, intact cells, and murine and human patient-derived material, with high sens...