Objectives: The primary focus in the rehabilitation services program is the universal coverage of these services, in other words, to provide better access to these services in any place and situation. The present study aimed to develop and validate a physical rehabilitation accessibility assessment questionnaire as a standardized instrument that can be adaptable to people with physical disabili...

This chapter focuses on the biological roles of the glycans contained in glycoproteins. Today we know there is no unifYing function for the carbohydrates present in glycoproteins. They rather span the complete spectrum from being obviously unimportant to being crucial for the survival of an organism. In a crude scheme, their biological functions can be classif ed into two groups. On one hand, t...

High-mobility group box 1 protein (HMGB1) is a conserved protein with a variety of biological functions inside as well as outside the cell. When released by activated immune cells, it acts as a proinflammatory cytokine. Its delayed release has sparked the interest in HMGB1 as a potential therapeutic target. Here, we studied the adsorption of HMGB1 to anionic methacrylate-based polymers as well ...

In recent years, the cost of DNA sequencing has decreased at a rate that has outpaced improvements in memory capacity. It is now common to collect or have access to many gigabytes of biological sequences. This has created an urgent need for approaches that analyze sequences in subsets without requiring all of the sequences to be loaded into memory at one time. It has also opened opportunities t...

Furin cleaves diverse types of protein precursors in the secretory pathway. The substrates for furin cleavage possess a specific 20-residue recognition sequence motif. In this report, based on the functional characterisation of the 20-residue sequence motif, we developed a furin cleavage site prediction tool, PiTou, using a hybrid method composed of a hidden Markov model and biological knowledg...

Although Turing pattern is one of the most universal mechanisms for pattern formation, in its standard model the number of stripes changes with the system size, since the wavelength of the pattern is invariant. It fails to preserve the proportionality of the pattern, i.e. the ratio of the wavelength to the size, that is often required in biological morphogenesis. To get over this problem, we sh...

This comprehensive guide, by pioneers in the field, brings together, for the first time, everything a new researcher, graduate student or industry practitioner needs to get started in molecular communication. Written with accessibility in mind, it requires little background knowledge, and provides a detailed introduction to the relevant aspects of biology and information theory, as well as cove...