In this study, a 4D dosimetry concept was developed. This concept included a method for calculation of 3D reference absorbed dose matrices at every control point of the delivery using a clinical treatment planning system (TPS). Further, the gamma evaluation method was extended to incorporate the 4 dimension of the TPS calculated dose distributions. The applications of the 4D dosimetry concept o...

Fricke gel dosimetry is a valuable method for in-phantom dose measurements in complex irradiation modalities like IMRT and BNCT. Implementation of this dosimetry technique requires dedicated instruments capable of measuring and further analysis immediately in situ at the radiation facility. This work presents a novel and integral dosimetry system aimed to attain portability requirements. The me...

Radiation dosimetry is fundamental in Medical Physics, involving patients and phantom dosimetry. In both cases thennoluminescence dosimetry (TLD) is the most appropriate technique for measuring the absorbed dose. In this paper thennoluminescence phenomenon as well as the use of TLD in radiodiagnosis and radiotherapy for in vivo or in phantom measurements is discussed. Some results of measuremen...

Ultrasoft x-rays are useful for testing the validity of mechanistic models of biological damage caused by radiation. Described here is the construction and operation of a cold-cathode transmission-target discharge tube for irradiating mammalian cells in vitro with aluminium characteristic x-rays (1.487 keV). Particular attention is given to the problems of sample preparation and dosimetry for t...

An urgent requirement for 3D dosimetry has been recognized because of high failure rate (~25%) in RPC credentialing, which relies on point and 2D dose measurements. Comprehensive 3D dosimetry is likely to resolve more errors and improve IMRT quality assurance. This work presents an investigation of the feasibility of PRESAGE/optical-CT 3D dosimetry in the Radiologic Physics Center (RPC) IMRT H&...

For risk assessment, it is necessary to evaluate the dose of human exposure to radiation. Ionizing radiation being an environmental genotoxic factor induces dosedependent somatic mutations. Recent studies support the somatic-mutation theory of carcinogenesis. Mutations at the Glycophorin–A (GPA) loci have been studied for establishment of somatic mutation assays. GPA assay provides a lifetime b...

The potential of targeted therapy with radiolabeled peptides has been reported in several clinical trials. Although there have been many improvements in dose estimation, a general and reliable dosimetric approach in peptide receptor radionuclide therapy (PRRT) is still a matter of debate. This article reviews the methods for PRRT dosimetry and the results presented in the literature. Radiopharm...