Optical imaging using multiphoton microscopy and whole body near infrared imaging has become a routine part of biomedical research. However, optical imaging methods rely on the availability of either small molecule reporters or genetically encoded fluorescent proteins, which are challenging and time consuming to develop. While directly labeled antibodies can also be used as imaging agents, anti...

Spectral Domain Optical Coherence Tomography System Development for In Vivo Ophthalmic Imaging by Mingtao Zhao Department of Biomedical Engineering Duke University Date:____September 17, 2009____________ Approved: ___________________________ Joseph A. Izatt, Supervisor ___________________________ David J. Brady ___________________________ Vo-Dinh Tuan ___________________________ Adam P. Wax ___...

Microfluidic devices are widely used for biomedical applications based on microscopy or other optical detection methods. However, the materials commonly used for microfabrication typically have a high refractive index relative to water, which can create artifacts at device edges and limit applicability to applications requiring high-precision imaging or morphological feature detection. Here we ...

The sixth Inter-Institute Workshop on Optical Imaging from Bench to Bedside was held at the National Institutes of Health (NIH) in Bethesda, Maryland, in October 2009. The broad impact of biophotonics on biomedical research was exemplified by the generous support that was provided by several diverse institutes and centers within NIH. These included the National Heart, Lung, and Blood Institute ...

The sixth Inter-Institute Workshop on Optical Imaging from Bench to Bedside was held at the National Institutes of Health (NIH) in Bethesda, Maryland, in October 2009. The broad impact of biophotonics on biomedical research was exemplified by the generous support that was provided by several diverse institutes and centers within NIH. These included the National Heart, Lung, and Blood Institute ...

Gold nanoparticles are the subject of intense studies due to the exceptional photo-optical properties combined with the biocompatibility and has proved to be a powerful tool in various nanomedicinal applications. This book chapter discusses the recent advances and current challenges facing the biomedical applications of gold nanoparticles of various sizes and shapes. This chapter summarizes the...

Differential spectral interferometry (DSI), a novel method of biomedical imaging that combines the high dynamic range of optical coherence tomography (OCT) with inherently parallel low-bandwidth image acquisition of spectral interferometry (SI), is described. DSI efficiently removes the deleterious dc background inherent in SI measurements while maintaining the parallel nature of SI. We demonst...

ABSTRACT Measurement of breast tissue response to external stimulation has the potential to unveil additional dynamic biomarkers of disease states. Recently tumor contrast generated by breathing-gas induced vascular changes has been demonstrated using both BOLD imaging [1] and MRIguided near infrared diffuse optical tomography [2]. At the same time, in the biomedical optics community, temporall...

Black phosphorus (BP), also known as phosphorene, has attracted recent scientific attention since its first successful exfoliation in 2014 owing to its unique structure and properties. In particular, its exceptional attributes, such as the excellent optical and mechanical properties, electrical conductivity and electron-transfer capacity, contribute to its increasing demand as an alternative to...

Three-dimensional cell-based tissue models have been increasingly useful in the fields of tissue engineering, drug discovery, and cell biology. While techniques for building these tissue models have been advanced, there have been increasing demands for imaging techniques that are capable of assessing complex dynamic three-dimensional cell behavior in real-time and at larger depths in highly-sca...