The Ugi reaction is found to be a very powerful tool for the synthesis of (pre)tubulysin derivatives, allowing the introduction of various functionalized side chains in only one step. While polar groups such as amides are not well tolerated, unpolar side chains such as allyl or propargyl ether are well accepted. These functionalities also allow subsequent modifications in the side chain, e.g. v...

The reaction of 2,2′-diiodo-1,1′-biphenyl (1a) with ethynyl ferrocene (2) gave trace amounts the expected 2,2′-bis(ferrocenylethynyl)-1,1′-biphenyl (3) together 9-(ferrocenyl(ferrocenylethynyl)methylene)-9H-fluorene (4), formed via a cyclization process during Sonogashira cross-coupling reaction, as major product. In contrast, similar 2,2′-diiodo-1,1′-diphenyl ether analogue 2 anticipated 2,2′-...

Self-assembly of a tribenzo-27-crown-9 ether functionalized with six terpyridines generated (85%) an expanded tetrahedral structure comprised of four independent triangular surfaces interlinked by crown ether vertices.

We report the draft genome sequence of Alternaria alternata ATCC 34957. This strain was previously reported to produce alternariol and alternariol monomethyl ether on weathered grain sorghum. The genome was sequenced with PacBio technology and assembled into 27 scaffolds with a total genome size of 33.5 Mb.

In the title compound, C(10)H(7)N(3)O(3), the dihedral angle between the two aromatic rings is 87.5 (1) Å; their ipso-C atoms subtend an angle of 117.4 (1)° at the ether O atom.

In the title compound, C(10)H(8)N(2)O, the dihedral angle between the aromatic rings is 64.2 (1)° and the bridging C-O-C angle is 119.1 (1)°.

Reactivation of organophosphate (OP)-inhibited acetylcholinesterase (AChE) by oximes is the primary reason for their effectiveness in the treatment of OP poisoning. Reactivation is reported to accelerate by quaternary ligands such as decamethonium, which is devoid of nucleophilicity. The mechanism of this enhancement is not known. To better understand the acceleration phenomenon, we examined li...

The title compound, C(40)H(40)O(9), is a product of the double crotonic condensation of bis-(2-acetyl-phen-oxy)-3-oxapentane with bis-(2-formyl-phen-oxy)-3,6-dioxaoctane. The title macromolecule includes the 31-crown-7-ether skeletal unit and adopts a saddle-like conformation. The two ethyl-ene fragments have E configurations. The volume of the inter-nal cavity of the macrocycle is approximatel...

Thin films made of a polymer (cellulose triacetate, CTA) and plasticizer have been studied as novel sorptive phases for chlorpyrifos, triclosan tonalide. The preparation is reproducible only requires the to be added into an organic dispersion containing CTA. evaporation solvent leaves easy manipulate continuous homogeneous thin film, which has investigated in terms both composition extraction e...

Bis(benzotriazol-1-yl)phenylmethane CHPh(btz)2 and tris(benzotriazol-1-yl)methane CH(btz)3 were used as N-donor ligands to prepare luminescent heteroleptic copper(I) complexes. [Cu{CHPh(btz)2}(PPh3)2][BF4] [Cu{CHPh(btz)2}(DPEphos)][BF4] (DPEphos = bis[(2-diphenylphosphino)phenyl] ether) obtained from the corresponding borohydride complexes [Cu(BH4)(PPh3)2] [Cu(BH4)(DPEphos)] tetrafluoroboric ac...