OBJECTIVES To examine whether the effect of tranexamic acid on the risk of death and thrombotic events in patients with traumatic bleeding varies according to baseline risk of death. To assess the extent to which current protocols for treatment with tranexamic acid maximise benefits to patients. DESIGN Prespecified stratified analysis of data from an international multicentre randomised contr...

AIM In the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial, apixaban compared with warfarin reduced the risk of stroke, major bleed, and death in patients with atrial fibrillation. In this ancillary study, we evaluated clinical consequences of major bleeds, as well as management and treatment effects of warfarin vs. apixaban. METHODS A...

Objectives To examine whether the effect of tranexamic acid on the risk of death and thrombotic events in patients with traumatic bleeding varies according to baseline risk of death. To assess the extent to which current protocols for treatment with tranexamic acid maximise benefits to patients. Design Prespecified stratified analysis of data from an international multicentre randomised control...

CONTEXT Randomized trials have shown that aspirin decreases the risk of cardiovascular events in patients with symptomatic coronary and cerebrovascular disease. Despite guideline recommendations for secondary prevention in peripheral artery disease (PAD), the effect of aspirin in this population is not well established. OBJECTIVE To investigate the effect of aspirin on cardiovascular event ra...

Quantification of the bleeding severity by use of bleeding assessment tools (BAT) and bleeding score (BS) has been consistently shown to improve the clinical diagnosis of von Willebr disease (VWD) while helping researchers establish phenotype/genotype correlations. Subjects with a BS equal or higher than 3 may be consider having a bleeding tendency, and should be referred for a laboratory inves...

OBJECTIVE To assess the efficacy of tranexamic acid or mefenamic acid in the management of the initial "nuisance" bleeding or spotting in the period immediately after placement of the levonorgestrel-releasing intrauterine system. METHODS Women were randomized after levonorgestrel-releasing intrauterine system placement to oral tranexamic acid (500 mg), mefenamic acid (500 mg), or placebo thre...

According to recommendations of ESC 2020-year, de-escalation therapy with a P2Y12 receptor inhibitor (transition from prasugrel or ticagrelor clopidogrel) It can be considered as an alternative strategy dual antiplatelet (DAPT) for patients acute coronary syndrome (ACS) who are unsuitable the use strong platelet inhibitor. De-escalation performed based on individual clinical evaluation under su...

• Description: Bleeding can result from a reduction in platelets, an alteration in clotting factors, a paraneoplastic syndrome, infection, hepatic problems, or a combination of these factors. Venous thromboembolism (VTE) includes both deep vein thrombosis (DVT) and pulmonary embolism (PE). • Incidence: Bleeding can occur with any type of cancer but especially in patients with advanced cancer an...

background: vaginal bleeding is a common complication during pregnancy, which is observed in about 1/4 of pregnancies and in half of cases can lead to abortion. if vaginal bleeding happens during pregnancy some adverse pregnancy outcomes, including perinatal mortality and morbidity, low birth weight and preterm delivery will be increased. objective:  the aim of this study was to determine the r...

BACKGROUND Major adverse cardiac events (MACEs) are a common cause of death after non-cardiac surgery. Despite evidence for the benefit of aspirin for secondary prevention, it is often discontinued in the perioperative period due to the risk of bleeding. METHODS We conducted a randomized, double-blind, placebo-controlled trial in order to compare the effect of low-dose aspirin with that of pl...