BACKGROUND Liver microcirculation can be affected by a wide variety of causes relevant to liver transplantation and resectional surgery. Intraoperative assessment of the microcirculation could possibly predict postoperative outcome. The present pilot study introduces laser speckle contrast imaging (LSCI) as a new clinical method for assessing liver microcirculation. METHODS LSCI measurements ...

Objective: Collateral circulation is essential for cerebral perfusion and the maintenance of metabolism function. The clinical factors affecting collateral in brain still unknown. In presence slowly developing stenosis, decrease blood flow can be compensated by adequate circulation, signs hemodynamic deterioration may not observed. Case: This case with a 6-year retrospective record only right I...

We analyzed the incidence and interaction of arteriolar vasomotion and capillary flow motion during critical perfusion conditions in neighboring peripheral tissues using intravital fluorescence microscopy. The gracilis and semitendinosus muscles and adjacent periosteum, subcutis, and skin of the left hindlimb of Sprague-Dawley rats were isolated at the femoral vessels. Critical perfusion condit...

This study aimed to elucidate possible age-related changes in islet blood perfusion in lean and obese C57BL/6 mice. Obese mice aged 1 mo were hyperglycemic and hyperinsulinemic and had an increased islet blood flow compared with age-matched lean mice. This augmented blood flow could be abolished by pretreatment with leptin. The islet blood perfusion was, in contrast to this, markedly decreased ...

Carlsson, Per-Ola, Arne Andersson, and Leif Jansson. Influence of age, hyperglycemia, leptin, and NPY on islet blood flow in obese-hyperglycemic mice. Am. J. Physiol. 275 (Endocrinol. Metab. 38): E594–E601, 1998.—This study aimed to elucidate possible age-related changes in islet blood perfusion in lean and obese C57BL/6 mice. Obese mice aged 1 mo were hyperglycemic and hyperinsulinemic and had...

Microcirculatory dysfunction plays a key role in the pathogenesis of tissue dysoxia and organ failure sepsis. Sublingual videomicroscopy techniques enable real-time non-invasive assessment microvascular blood flow. Alterations sublingual perfusion were detected during sepsis are associated with poor outcome. More importantly, allowed to explore effects commonly applied resuscitative treatments ...

Abstract SARS-CoV-2 uses ACE2, an inhibitor of the Renin-Angiotensin-Aldosterone System (RAAS), for cellular entry. Studies indicate that RAAS imbalance worsens prognosis in COVID-19. We present a consecutive retrospective COVID-19 cohort with findings frequent pulmonary thromboembolism (17%), high artery pressure (60%) and lung MRI perfusion disturbances. demonstrate, swine, infusing angiotens...

Abstract Purpose of Review This review discusses applications transcranial Doppler (TCD) in cardiac surgery, its efficacy preventing adverse events such as postoperative cognitive decline and stroke, impact on clinical outcomes these patients. Recent Findings TCD alone combination with other neuromonitoring modalities has attracted attention a potential monitoring tool surgery allows not only t...

Background Heart failure (HF) is a condition characterized by increased filling pressures in the left ventricle due to altered cardiopulmonary blood flow. However, there are no clinically available non-invasive quantitative methods to measure filling pressures in HF. The pulmonary blood volume variation (PBVV) indexed to stroke volume (SV) by cardiac magnetic resonance (CMR) could be a novel no...

We assessed transmurally the coronary autoregulatory response to elevated perfusion pressure in 85 anesthetized, open-chest dogs. Steady state and transient flow distributions were measured with 9 ± 1 /im radioactive microspheres. Steady state distributions of myocardial blood flow were uniform transmurally (P > 0.05) at perfusion pressures of 103 ± 1 (n = 81) and 146 ± 2 (n = 34) mm Hg, wherea...