OBJECTIVE To assess baroreflex intervention during increase in left ventricular afterload, we compared the effects of aortic banding on the intact cardiovascular system and under hexamethonium infusion. METHODS Six open-chest pigs, instrumented for measurement of aortic pressure and flow, left ventricular pressure and volume, were studied under pentobarbital-sufentanil anesthesia. Vascular ar...

1. We investigated the vagal pathways mediating the gastric accommodation reflex in the rat stomach. 2. Gastric distension (6 ml) evoked an increase of 9.0 +/- 1.0 cmH2O of intragastric pressure in vivo. Pretreatment with tetrodotoxin (TTX) caused a significant pressure increase by gastric distension, reaching 17.0 +/- 1.7 cmH2O, suggesting mediation by neural pathways. 3. The pressure increase...

We have previously shown that mice transgenic for both the human renin and human angiotensinogen genes (RA+) exhibit appropriate tissue- and cell-specific expression of both transgenes, have 4-fold higher plasma angiotensin II (AII) levels, and are chronically hypertensive. However, the relative contribution of circulating and tissue-derived AII in causing hypertension in these animals is not k...

Stimulation of the vagal trunk in cats anesthetized with pentobarbital sodium produced a contractile response of the stomach during stimulation (initial contraction). Pretreatment with either hexamethonium (0.3 to 30 mg/kg, i.v.) or gallamine (1 to 100 mg/kg, i.v.) dose-dependently produced a delayed contraction, following the initial contraction after stimulation. After the administration of e...

a periodic increase in blood pressure (bp) occurs during apneic episodes in patients with obstructive sleep apnea (osa). several factors including hypoxemia and an increase in heart rate (hr) were reported to be responsible for this increased bp. to examine the contribution of these two factors in increasing bp, 35 healthy male subjects (mean age±sd= 23.64±3.80) were studied in three experiment...

objective: for many years in herbal medicine the antihypertensive and lowering blood lipid properties of achillea wilhelmsii (a. wilhelmsii) have been suggested. in the present study the impacts of the plant extract on rabbit’s blood pressure and heart rate have been investigated. materials and methods: twelve nwz rabbits weighed 2-3 kg were randomly divided into two groups of 6 rabbits. the te...

background: normal standard references of blood pressure (bp) for children and adolescents have been suggested to be constructed based on anthropometric indices. accordingly, we aimed to develop first bp reference percentiles by weight and age for iranian children aged 3-18 years old. materials and methods: a total of 16,246 children and adolescents aged 3-18 years were included from 3 cross-se...