Blood vessel network formation is a pivotal process of physiological development and pathological conditions such as tumor growth, diabetic retinopathy, and cardiovascular diseases.1,2 During neovascularization, vasculogenesis is followed by the well-described process of sprouting angiogenesis, including tip cell induction and selection, sprout elongation, and stalk formation, leading to the fo...

OBJECTIVE To evaluate the outcomes of major vessel reconstruction as part of surgery to remove sarcomas. DESIGN Retrospective review. SETTING Tertiary academic medical center. PATIENTS Fourteen patients (10 female) with retroperitoneal or extremity sarcomas and major blood vessel involvement who underwent surgery to remove the tumor and had blood vessel reconstruction between 2003 and 200...

Retinal vessel segmentation algorithms are important in automatic retinal disease screening systems. Images captured from fundus camera are useful in screening various diseases affecting retina by processing the images for better diagnosis and planning of treatment. Ophthalmology is a branch of biomedical field which requires computer aided automated techniques for pathology identification in h...

INTRODUCTION THE experimental production of corneal vascularisation has been performed by various workers. Ehlers (1927) made daily applications of ethyl alcohol to rabbits' corneae resulting in a loss of corneal transparency 'and an ingrowth of vessels from all round the limbus into the anteri6r two-thirds of the cornea. Julianelle (1933) produced " pannus " formation by intra-corneal injectio...

In the smallest capillaries, or in tubes with diameter D 8 μm, flowing red blood cells are well known to organize into single-file trains, with each cell deformed into an approximately static bullet-like shape. Detailed high-fidelity simulations are used to investigate flow in a model blood vessel with diameter slightly larger than this: D=11.3 μm. In this case, the cells deviate from this sing...

The segmentation of retinal blood vessels in the retina is a critical step in diagnosis of diabetic retinopathy. In this paper, we present a new method for automatically segmenting blood vessels in retinal images. Five basic algorithms for segmenting retinal blood vessels, based on different image processing techniques, are described and their strengths and weaknesses are compared. A hybrid alg...

The formation of a polygonal configuration of proto-blood-vessels from initially dispersed cells is the first step in the development of the circulatory system in vertebrates. This initial vascular network later expands to form new blood vessels, primarily via a sprouting mechanism. We review a range of recent results obtained with a Monte Carlo model of chemotactically migrating cells which ca...

A BSTRACT : We have developed a multistage image analysis technique for the simultaneous segmentation of blood vessels and hypoxic regions in dualstained tumor tissue sections. The algorithm, which is integrated in a task-oriented image analysis system developed on-site, initially uses the K -nearest neighbor classification rule in order to label the image pixels. Classification is based on a t...

Despite major advances in the field of tumor angiogenesis, relatively little attention has been paid to the permeability of blood vessels in tumors. The leakiness of tumor vessels is well documented in experimental tumor models and in human cancer, but the mechanism is poorly understood, as are the implications to the rate of cancer growth, predisposition to metastasis, and delivery of macromol...