نتایج جستجو برای: bnct
تعداد نتایج: 489 فیلتر نتایج به سال:
Boron neutron capture therapy (BNCT) is an effective method for treatment of deep seated brain tumors. This method consists of two stages: injection of boron compound in the patient body, and then irradiation of the region tumors with the neutron beam. It allows for delivery of high linear energy transfer (LET) radiation (particles 4He and 7Li nuclei) to tumors at the cellular level whilst avoi...
Abstract Background p -Boronophenylalanine ( 10 BPA) is a powerful B drug used in current clinical trials of BNCT. For BNCT to be successful, high (500 mg/kg) dose BPA must administered over few hours. Here, we report efficacy after rapid, ultralow-dose administration either tumor vasculature-specific annexin A1-targeting IFLLWQR (IF7)-conjugated or borocaptate sodium BSH). Methods (1) IF7 conj...
PURPOSE The purpose of the present study was to evaluate a boronated EGFRvIII-specific monoclonal antibody, L8A4, for boron neutron capture therapy (BNCT) of the receptor-positive rat glioma, F98(npEGFRvIII). EXPERIMENTAL DESIGN A heavily boronated polyamido amine (PAMAM) dendrimer (BD) was chemically linked to L8A4 by two heterobifunctional reagents, N-succinimidyl 3-(2-pyridyldithio)propion...
Drug delivery through the Blood–Brain Barrier (BBB) represents a significant challenge. Despite current strategies to circumvent BBB, nanotechnology offers unprecedented opportunities for combining selective delivery, improved bioavailability, drug protection, and enhanced pharmacokinetics profiles. Chitosan nanocarriers allow more efficacious strategy at cellular sub-cellular levels. Boron Neu...
PURPOSE Boron neutron capture therapy (BNCT) is a radiotherapeutic modality based on (10)B(n,alpha)(7)Li reaction, for the treatment of malignant gliomas. One of the main limitations for BNCT effectiveness is the insufficient intake of (10)B nuclei in the tumor cells. This work was aimed at investigating the use of L-DOPA as a putative enhancer for (10)B-drug 4-dihydroxy-borylphenylalanine (BPA...
The main detectors used for clinical dosimetry are ionisation chambers and semiconductors. Thermoluminescent (TL) dosimeters are also of interest because of their following advantages: i) wide useful dose range, ii) small physical size, iii) no need for high voltage or cables, i.e. stand alone character, and iv) tissue equivalence (LiF) for most radiation types. TL detectors can particularly be...
Boron neutron capture therapy (BNCT) is a form of chemically targeted radiotherapy that utilises the high neutron capture cross-section of boron-10 isotope to achieve a preferential dose increase in the tumour. The BNCT dosimetry poses a special challenge as the radiation dose absorbed by the irradiated tissues consists of several dose components with different relative biological effectiveness...
Success of boron neutron capture therapy (BNCT) is dependent on cellular and molecular targeting of sufficient amounts of boron-10 to sustain a lethal B (n, ) Li capture reaction. The purpose of the present study was to determine the efficacy of boronated epidermal growth factor (EGF) either alone or in combination with boronophenylalanine (BPA) as delivery agents for an epidermal growth factor...
Introduction: Boron neutron capture therapy (BNCT) is recommended to treat the glioblastoma tumor. It is well known that neuron beams are more effective treatment than photon beams to treat hypoxia tumors due to interaction of neutron with nucleus and production of heavy particles such as 7Li and alpha particle. In this study to evaluate the suitability of BNCT for treating of ...
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