BACKGROUND Perceived Health Related Quality of Life (HRQoL) is impaired in obstructive sleep apnea (OSA). This study examines changes in HRQoL aspects occurring immediately after CPAP titration. Furthermore, we analyzed variations in each gender and in patients undergoing home or laboratory-based CPAP titration pathways. METHODS Twohundredfive outpatients (151 M) (56.7 ± 10.3 years) were eval...

This paper presents a theoretical analysis of the titration behavior of strongly interacting titratable residues in proteins. Strongly interacting titratable residues exist in many proteins such as for instance bacteriorhodopsin, cytochrome c oxidase, cytochrome bc(1), or the photosynthetic reaction center. Strong interaction between titratable groups can lead to irregular titration behavior. W...

Objective: Continuous positive airway pressure (CPAP) is the treatment of choice for patients diagnosed with severe obstructive sleep apnea (OSA). The implementation of CPAP therapy has traditionally been based on full-night titration studies or split-night protocols. This study compared a group of patients who received a regular nocturnal CPAP titration with patients who received a daytime CPA...

A decade ago, investigators in oncology had a clear interest in modifications to the standard phase 1 design to make it more efficient, to treat fewer patients at non-toxic dose levels (which may be less efficacious), and to increase the precision of phase 2 dose recommendations. This was the conclusion of the 1996 joint meeting of the U.S. National Cancer Institute and the European Organizatio...

Nevertheless there are two fundamentally different ways [2] of identifying sets of data. First, the cumulative collection of test results may be checked for plausibility. Mislabelled [3] results will be recognised if they differ greatly from those recorded earlier. The method, however, is not very effective as Sheiner et al [16] have shown. A Delta check method, [4] controlled by a computer, di...

BACKGROUND Custom oral appliances that adjustably advance the mandible provide superior outcomes when treating patients with moderate or severe sleep apnea. Custom appliances, however, are expensive, must be fitted by a dentist, and the likelihood of successful outcomes are difficult to predict. An inexpensive trial appliance, if proven efficacious, might be used to predict custom appliance out...

PURPOSE Treatment of hypertension is expensive and cost is one of the reasons for inadequate blood pressure control. Where there are no social cost cushions, the burden is borne by patients. With pervasive poverty and inadequate control, complications are unchecked. Back titration in appropriate circumstances should, therefore, translate to economic benefit. This is an attempt to compute, in ec...