Background: Nowadays, the most important aspect of hemodialysis is the technical method of anticoagulation of extracorporeal circuit. This quasi-experimental study was performed to compare three methods of heparinization in the extracorporeal circulation. Methods: Twenty-seven hemodialysis patients referring to Rafsanjan Hemodialysis Center with the weight range of 50-90 kg and normal Clotting ...

The present study examined the long-term efficacy of insulin pump therapy for type 1 diabetes patients when carried out using carbohydrate counting with bolus calculators for 1 year. A total of 22 type 1 diabetes patients who had just started continuous subcutaneous insulin infusion were examined and divided into two groups: one that was educated about carbohydrate counting using bolus calculat...

Abstract Background Oral corticosteroids remain as the first-line treatment for moderately active ulcerative colitis (UC). In controlled studies, they achieved clinical remission in 30-60% of patients at 30 days. severe systemic diseases, intravenous bolus administration methyl-prednisolone accelerates response and increases therapeutic efficacy corticosteroids. Aims To assess additive effect I...

Simulations of the influence of contrast agent bolus dispersion on the shape of the contrast agent bolus and on quantification of myocardial blood flow (MBF) have been made using an exponential residue function model, and an computational fluid dynamics (CFD) approach. Based on the exponential residue function model, up to 20% underestimation of MBF appeared reasonable. CFD simulations showed t...

BACKGROUND Tirofiban administered at a bolus dose of 25 mcg/kg is associated with a higher level of platelet inhibition compared to that associated with the standard 10 mcg/kg tirofiban bolus dose. In our previous study on bolus-only glycoprotein IIb/IIIa receptor inhibition during percutaneous coronary intervention (PCI), the eptifibatide bolus-only group demonstrated similar efficacy, but sig...

BACKGROUND Complement activation mediates myocardial damage that occurs during ischemia and reperfusion through multiple pathways. We performed 2 separate, parallel, double-blind, placebo-controlled trials to determine the effects of pexelizumab (a novel C5 complement monoclonal antibody fragment) on infarct size in patients receiving reperfusion therapy: COMPlement inhibition in myocardial inf...

Feasibility study of the best monitoring time-interval to track contrast agent bolus in dual-source coronary computed tomography angiography