OBJECTIVE There are strong indications that subchondral bone may play an important role in osteoarthritis (OA), making it an interesting target for medical therapies. The subchondral bone structure changes markedly during OA, and it has long been assumed that this occurs secondary to cartilage degeneration. However, for various conditions that are associated with OA, it is known that they may a...

There has been little mention in the British literature of the bone and joint changes that may be associated with haemochromatosis. These changes consist of osteoporosis, opacification of menisci identical with chondrocalcinosis, and an arthropathy (Delbarre, 1960, 1964) which can affect the larger joints but which afflicts, in particular, the proximal interphalangeal and metacarpophalangeal jo...

osteoporosis is a skeletal disease characterized by reduction in bone mass and micro architectural changes in the bone, which leads to increased bone fragility. the gold standard for the diagnosis of osteoporosis is the measurement of bone mineral density (bmd) by dual energy x-ray absorptiometry (dxa). periodontal disease is a chronic destructive disease which can occur in adults, young people...

Primary hyperparathyroidism (HPTH) is a known risk factor for cortical bone loss. The primary objective of this study was to examine the time course and location of changes in bone mass within the first year after parathyroidectomy (PAX). The secondary goal was to evaluate the efficacy of combined estrogen therapy and parathyroidectomy in postmenopausal women. Thirty-two subjects with primary H...

Once a disease is known to be becoming rare, it tends to be forgotten and this may cause diagnostic difficulty. In the United Kingdom this applies to tuberculosis as a whole, the incidence of which continues to decline, and particularly to bone and joint tuberculosis. Our paper, a review of all cases of bone and joint tuberculosis in North Staffordshire over a five-year period, is a reminder th...

The following position statement is issued by the American Society for Metabolic and Bariatric Surgery for enhancing quality of care in bariatric surgery. In this statement, suggestions for management are presented that are derived from available knowledge, peer-reviewed scientific literature and expert opinion regarding monitoring and treatment of metabolic bone changes after bariatric surgery...

Ribs from 3 preterm infants, who had died after prolonged intravenous feeding and artificial ventilation, were examined histologically and assessed for the degree of osteomalacia and osteoporosis in cancellous bone of the shaft. A grid counting technique was used. Osteomalacia was noted in all 3 cases but to a lesser degree than in classical vitamin D-deficient controls. Osteoporosis was pronou...

Much success has been reported in the treatment of leprosy within the past seven years from those countries where the sulfone drugs promin, diasone and promizole have been used (1-6). Similarly encouraging therapeutic results have been reported within recent months for another related sulfone called sulfetrone (7). All of these reports seem to indicate that, thus far, the chief value of the sul...

Twenty-five patients with congenital cyanotic heart disease were studied. Skiagrams of the skull (posteroanterior and lateral views), pelvis and lumbar spine (posteroanterior and lateral views), upper limb (posteroanterior view only), and x-ray of ankle joint including lower ends of tibia and fibula (posteroanterior and lateral views) were taken. Haemoglobin, packed cell volume, total leucocyte...