نتایج جستجو برای: bone marrow stromal cells bmsc
تعداد نتایج: 1637542 فیلتر نتایج به سال:
Adiponectin (APN), the most abundant adipocyte-secreted adipokine, regulates energy homeostasis and exerts well-characterized insulin-sensitizing properties. The peripheral or central effects of APN regulating bone metabolism are beginning to be explored but are still not clearly understood. In the present study, we found that APN-knockout (APN-KO) mice fed a normal diet exhibited decreased tra...
BACKGROUND AND PURPOSE Bone marrow stromal cells (BMSC) decrease neurological deficits in rodents after stroke and concomitantly induce extensive neurite remodeling in the brain, which highly correlates with the improvement of neurological function. We investigated the effects of endogenous tissue plasminogen activator (tPA) on neurite remodeling after BMSC treatment. METHODS Adult C57BL/6 wi...
Lung fibrosis is characterized by vascular leakage and myofibroblast recruitment, and both phenomena are mediated by lysophosphatidic acid (LPA) via its type-1 receptor (LPA1). Following lung damage, the accumulated myofibroblasts activate and secrete excessive extracellular matrix (ECM), and form fibrotic foci. Studies have shown that bone marrow-derived cells are an important source of myofib...
The hypoxia-inducible factors (HIFα) are the critical factors that couple angiogenesis and osteogenesis by activating transcription of VEGF in osteoblasts. Mice lacking von Hippel-Lindau gene (Vhl), thus overexpressing HIFα in osteoblasts develop extremely dense and highly vascularized long bones. Here we provide evidence that osteoblasts lacking Vhl overexpress and secrete high levels of VEGF,...
INTRODUCTION: The medical application of low-intensity pulsed ultrasound (LIPUS) is an established therapy for fracture repair. Despite its pronounced effects during fracture repair, the underlying mechanisms of action of LIPUS remain unclear. Cell-to-cell communication is critical for bone development and remodeling. In the bone marrow, nonhematopoietic-bone marrow stromal cells (BMSC) provide...
Telomere shortening and telomerase deficiency have been linked with several age related degenerative diseases. Moreover, degenerative changes in various tissues/organs have been attributed to derangement of stem cell functions causing regenerative tragedy. Bone marrow stromal cells (BMSCs) are considered the ideal candidates for regenerative approaches owing to their beneficial effects in numer...
Stem cells can be differentiated into cardiomyocytes by induction with 5-azacytidine (5-aza) but its carcinogenicity is of concern for future translational application. Alternatively, growth factors and hormones such as basic fibroblast factor (bFGF) hydrocortisone have been reported to act a therapeutic inducer differentiation. In this study, we aim investigate the ability bFGF in combination ...
The low incidence of CFU-F significantly complicates the isolation of homogeneous populations of mouse bone marrow stromal cells (BMSCs), a common problem being contamination with hematopoietic cells. Taking advantage of burgeoning evidence demonstrating the perivascular location of stromal cell stem/ progenitors, we hypothesized that a potential reason for the low yield of mouse BMSCs is the f...
BACKGROUND Cell transplantation is likely to become an important therapeutic tool for the treatment of various traumatic and ischemic injuries to the central nervous system (CNS). However, in many pre-clinical cell therapy studies, reporter gene-assisted imaging of cellular implants in the CNS and potential reporter gene and/or cell-based immunogenicity, still remain challenging research topics...
Purpose: The assessment of the ability of combined treatment of bone marrow stromal cells graft (BMSCs) and oral administration of Coenzyme (CoQ10) in rat model of Parkinson disease as a good substitute for common current Parkinson treatments, and the comparison of this combined treatment method with alone application of these treatments. Materials and Methods: In this experimental study of mal...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید