Hypothesis / aims of study The efficacy of α1-adrenergic antagonists in the treatment of lower urinary tract symptoms (LUTS) in patients with benign prostatic hyperplasia (BPH) is generally attributable to improvement of the urodynamic characteristics and relief of bladder instability. While the latter effect has been partly confirmed in an animal model with partial bladder outlet obstruction (...

The aim of the present study was to determine whether the treatment of obstructed rat bladders with αlipoic acid (ALA) and silymarin reverses the biochemical and physiological responses to bladder outlet obstruction (BOO). A total of 32 adult Sprague Dawley rats were divided into four groups (n=8 per group): sham (placebo surgery) animals with no treatment (group 1); control animals with surgic...

Major pelvic ganglion electrocautery (MPGE) and spinal cord injury in the rat induce bladder hypertrophy and a change in muscarinic receptor subtypes mediating bladder contraction from predominantly M3 to a combination of M2 and M3. To determine whether this is a result of bladder hypertrophy or denervation, we studied the following groups: sham-operated controls, urinary diversion (DIV), MPGE ...

Urgency is the core symptom of the overactive bladder symptom complex, but the underlying mechanisms are not fully understood. Clinical findings have led to the assumption that bladder outlet obstruction (BOO) caused by benign prostatic enlargement (BPE) induces storage symptoms and detrusor overactivity. Presumably, BOO by BPE accounts for urgency; however, urgency is not always caused by BOO....

Urodynamic tests are the standard diagnostic method for lower urinary tract dysfunctions (LUTD). However, these tests are invasive. The current review describes the noninvasive imaging techniques that have been used to monitor LUTD. The main imaging technologies that have been applied in diagnosing LUTD were 2D ultrasonography, Doppler ultrasonography, and near-infrared spectroscopy (NIRS). Ult...

PURPOSE To identify the prevalence and clinical features of detrusor underactivity (DU) in elderly men and women presenting with lower urinary tract symptoms (LUTS). MATERIALS AND METHODS We reviewed 1,179 patients aged over 65 years who had undergone a urodynamic study for LUTS with no neurological or anatomical conditions. DU was defined as a bladder contractility index <100 and a maximal f...

Background: Bladder outlet obstruction (BOO) is a clinical condition that characterized by impediment to the flow of urine. It affects all age groups with varying etiologies. The pattern this in our setting unknown. This study aimed at determines clinico-epidemiological BOO southwestern Nigeria. Method: We retrospectively reviewed case files patients were managed for over period 10years center....

PROGRESS REPORT OF REDTOL: THE RED ALGAL TREE OF LIFE Yoon, H. S. Sungkyunkwan University, Republic Of Korea, [email protected] Bhattacharya, D. Rutgers University, USA, [email protected] Boo, S. M. Chungnam National University, Republic Of Korea, [email protected] Fredericq, S. University of Louisiana at Lafayette, USA, [email protected] Hommersand, M. University of North Caro...

of Dissertation Presented to the Graduate School of the University of Florida in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy OPTIMIZATION METHODS IN INTENSITY MODULATED RADIATION THERAPY TREATMENT PLANNING By Dionne M. Aleman December 2007 Chair: H. Edwin Romeijn Major: Industrial and Systems Engineering The design of a treatment plan for intensity modulated r...

BACKGROUND With the increasing interest with botulinum toxin--A (BTX-A) application in the lower urinary tract, we investigated the BTX-A effects on the canine prostate and also in men with bladder outlet obstruction (BOO) due to benign prostatic hyperplasia (BPH). METHODS Transperineal injection into the prostate using transrectal ultrasound (TRUS) was performed throughout the study. Saline ...