Troubled by an unstable world beset new and emerging viruses? Virus evolution is here to help. Through detailed studies of poliovirus vaccine reversion virulence, Valesano colleagues remind us that some things in life can, indeed, be counted on. Live-attenuated vaccines are among the most impactful tools public health, having been widely used control viruses cause feared burdensome diseases kno...

BACKGROUND Good outcomes during pregnancy and childbirth are related to availability, utilisation and effective implementation of essential interventions for labour and childbirth. The majority of the estimated 289,000 maternal deaths, 2.8 million neonatal deaths and 2.6 million stillbirths every year could be prevented by improving access to and scaling up quality care during labour and birth....

This study aims to determine whether ramp meters increase the capacity of active freeway bottlenecks. The traffic flow characteristics at twenty-seven active bottlenecks in the Twin Cities have been studied for seven weeks without ramp metering and seven weeks with ramp metering. A methodology for systematically identifying active freeway bottlenecks in a metropolitan area is proposed, which re...