Botulinum neurotoxin (BoNT), the most toxic substance known to mankind, is the first example of the fully active molten globule state. To understand its folding mechanism, we performed urea denaturation experiments and theoretical modeling using BoNT serotype A (BoNT/A). We found that the extent of BoNT/A denaturation from the native state (N) shows a nonmonotonic dependence on urea concentrati...

BACKGROUND Botulinum toxin is widely used for facial aesthetics, and its use in men continues to increase. OBJECTIVE To provide a review of pertinent male anatomic features and updated clinical information on the use of botulinum toxin in men. METHODS A Medline search was performed for publications on sex differences in facial anatomy and on clinical studies examining the role of sex in bot...

Our data show that botulinum toxin A (BoNT/A) didn't influence motor functions in naïve and CCI-exposed rats, but diminished the neuropathic pain-related behavior. The results indicate that BoNT/A administration diminished the spinal Iba-1 positive cells activation and, in parallel, downregulated IL-1beta. Moreover, we observed that in DRG the protein level of pronociceptive factors (IL-1beta a...

This paper provides a review of the research literature that reports on the effectiveness of botulinum toxin-A (BtA) to reduce tone and improve functional use of the upper limbs of children who have cerebral palsy. Evaluation of the findings suggest that injections of BtA have demonstrated promising short-term results by reducing tone and increasing active range of motion in some children. Posi...

Our aim was to evaluate the effect of adding inhibitory casting to the treatment of young children with cerebral palsy who received injections of botulinum neurotoxin A (BoNT-A) to gastrocnemius for equinus gait. Of the 20 patients in the series, 11 in group A had inhibitory casts applied on the day of the first set of BoNT-A injections and nine in group B did not have casting. Both groups rece...

We report a case of unilateral transient mydriasis and ptosis after botulinum toxin injection applied by a medical doctor for a cosmetic procedure. A 36-year-old nurse was referred to our eye clinic with unilateral mydriasis and ptosis in the right eye 3 days after botulinum toxin injection for a cosmetic procedure. Botulinum toxin was applied to her eye by a doctor at her hospital who was not ...

The number of migraine treatments and our understanding of migraine pathophysiology are both increasing. Newer treatments focus on migraine prevention. Botulinum toxin (BTX) is a potent neurotoxin used primarily to treat diseases associated with increased muscle activity. Recently, BTX was found to have antinociceptive effects that are probably independent of its muscle-relaxant action. Clinica...

INTRODUCTION Previously, botulinum toxin type A (BTX-A) (Botox; Allergan, Irvine, Calif) was shown to be effective in reducing excessive gingival display in 5 patients with gummy smiles. This study was conducted to determine whether the doses and the primary injection sites used in the pilot study for the correction of gummy smiles provide consistent, statistically significant, and esthetically...

Prevention and treatment of abnormal scarring present a challenge to the medical fraternity. Herein, we report the beneficial effect of botulinum toxin A (BTA) for wound modulation in a case with post‐traumatic lower lid cicatricial ectropion. A 20‐year‐old male patient presented with severe cicatricial ectropion in his left lower lid with a scar going down to his cheek and to the ala of the no...

This information reflects FDA’s current analysis of available data concerning these drugs. Posting this information does not mean that FDA has concluded there is a causal relationship between the drug products and the emerging safety issue. Nor does it mean that FDA is advising healthcare professionals to discontinue prescribing these products. FDA is considering, but has not reached a conclusi...