Triple negative breast cancers (TNBC) lacking hormone receptors and HER-2 amplification are very aggressive tumors. Since relevant differences between primary tumors and metastases could arise during tumor progression as evidenced by phenotypic discordances reported for hormonal receptors or HER-2 expression, in this analysis we studied changes that occurred in our TNBC model IIB-BR-G throughou...

Refuges or shelters have been central to UK domestic violence service provision since the 1970s. In 2013, policy transformed teenagers into primary users of refuges. Digital technology is teenagers’ lives but moving a refuge can cause serious disruption in this respect.The study was undertaken 20 refuges England. Repeat qualitative interviews with young people aged 13–18 and single staff explor...

BACKGROUND Human epidermal growth factor receptor 2 (HER2) is an important biomarker whose status plays a pivotal role in therapeutic decision-making for breast cancer patients and in determining their clinical outcomes. Ensuring the accuracy and reproducibility of HER2 assays by immunohistochemistry (IHC) and by fluorescence in situ hybridization (FISH) requires a reliable standard for monitor...

Blast, Pyricularia grisea (Cooke) Sacc., is one of the most destructive diseases of rice worldwide and canresult in significant reductions in yield. The use of resistant cultivars is the most economical and effectiveway of controlling rice blast. A variety of DNA markers, including plant defense-related candidategene markers are available for genetic characterization and molec...

An experiment is described in which plasma flow to a tokamak limiter is controlled through the use of a local toroidal divertor coil mounted inside the limiter itself. This coil produces a local perturbed field Be approximately equal to the local unperturbed toroidal field B r ~ 3 kG, such that when Be adds to Br the field lines move into the limiter and the local plasma flow to it increases by...