Background and Objective: As one of the widely used drugs, aspirin (acetyl-salicylic acid, ASA) plays an important role in stroke treatment and prevention. In a previous study, we demonstrated ASA injection at 30 min after ischemia onset is neuroprotective. To determine whether the neurons protected by ASA had a normal ultrastructure, hippocampal CA1 pyramidal neurons were examined by Transm...

BACKGROUND AND PURPOSE Protein unfolding and aggregation are dominant early pathogenic events in neurons after brain ischemia. This study used a transient cerebral ischemia model to investigate whether overproduction of unfolded proteins after brain ischemia is a consequence of proteasome dysfunction. METHODS Proteasome peptidase activity and proteasome subcellular redistribution and assembly...

OBJECTIVES Recent studies have reported that cis element decoy oligodeoxynucleotides against nuclear factor-kappa B block the activation of genes that mediate ischemic injury. To improve brain protection during circulatory arrest in cardiac surgery, we evaluated the efficacy of nuclear factor-kappa B decoy oligodeoxynucleotides in preventing neuronal damage after global brain ischemia. METHOD...

Objective Vascular findings in preeclampsia are usually attributed to increased vascular tone. Recently, however, important studies have improved the understanding of main pathophysiological events this condition, especially brain remodeling, impaired autoregulation, and damage blood-brain barrier, which well recognized features cerebral overperfusion. Methods In study, association between chor...

Introduction: The aim of this review article was to analyze in details the mechanism drugs’ effects treatment and prevention a migraine attack, as well discuss hypotheses pathogenesis.
 Migraine attack agents: main agents for have an anti-nociceptive activity.
 Agents preventive treatment: β-blocker propranolol also has anti-serotonin analgesic activities, most drugs used prophylactic...

Identifying which specific neuronal phenotypes are vulnerable to neonatal hypoxia-ischemia, where in the brain they are damaged, and the mechanisms that produce neuronal losses are critical to determine the anatomical substrates responsible for neurological impairments in hypoxic-ischemic brain-injured neonates. Here we describe our current work investigating how the serotonergic network in the...

BACKGROUND Gene therapy may be a promising approach for treatment of brain ischemia, although the efficiency of postischemic gene therapy is not established. Our goal in this study was to examine the effects of gene transfer of interleukin-10 (IL-10), an antiinflammatory cytokine, after induction of brain ischemia. METHODS AND RESULTS Brain ischemia was produced by either photochemical occlus...