BACKGROUND We reviewed the current medical literature that pertained to the question of whether myocardial ischemia triggers the release of B-type natriuretic peptides (BNPs) and, in particular, whether transient exercise-induced ischemia can be detected by the measurement of changes in these biomarkers. BNPs are well-established as markers of left ventricular dysfunction, particularly heart fa...

Background We recently demonstrated that brain natriuretic peptide is expressed in the dorsal root ganglia, and that brain natriuretic peptide is required for normal detection of pruritogens. We further showed that the receptor for brain natriuretic peptide, natriuretic peptide receptor A, is present in the spinal cord, and elimination of these neurons profoundly attenuates scratching to itch-i...

Introduction: COPD is a common preventable disease characterized by airflow limitation that is not completely reversible.Acute exacerbation is prominent and serious features of COPD. Acute Exacerbation of COPD leads to hospitalization and concomitant with morbidity and mortality .The ventricular dysfunction increases serum Brain Natriuretic Peptide(BNP)  . This study was conducted to evaluate t...

P atients with type 2 diabetes often suffer from asymptomatic left ventricular (LV) injury, including increased LV mass, without apparent myocardial ischemia. The mechanisms underlying diabetic LV injury remain unclear; however, it has been suggested that endothelial dysfunction plays a role. Accumulating evidence indicates that bone marrow–derived endothelial progenitor cells (EPCs) contribute...

pulmonary hypertension (ph) is an important cause of heart failure in chronic obstructive pulmonary disease (copd). the pro brain natriuretic peptide n-terminal (nt-probnp) has been suggested as a noninvasive marker to evaluate ventricular function. however, there is no evidence to support the use of nt-probnp in monitoring the benefits of vasodilators in copd induced ph. thus, we used nt-probn...

Aim. To assess laboratory markers of hemodynamic status in patients with moderate to severe COVID-19. Materials and Methods. Here we examined 15 COVID-19 16 critically ill patients. The control group consisted 20 healthy volunteers. levels endothelin-1, brain natriuretic peptide (BNP), N-terminal pro-brain (NT-proBNP) were measured by enzyme-linked immunosorbent assay. amounts nitrites (NO 2 ) ...

INTRODUCTION In pulmonary embolism (PE) without hemodynamic compromise, the prognostic value of right ventricular (RV) dysfunction as measured by echocardiography, computed tomography (CT) or biological (natriuretic peptides) markers has only been assessed in small studies. METHODS Databases were searched using the combined medical subject headings for right ventricular dysfunction or right v...

Brain (B-type) natriuretic peptide (BNP) is a 32 amino acid peptide that is synthesized and released predominantly from ventricular myocardium in response to myocyte stretch. Like atrial natriuretic peptide (ANP), BNP seems to have almost exclusively beneficial physiological properties, including balanced vasodilation, natriuresis, and inhibition of both the sympathetic nervous system and the r...

OBJECTIVES The purpose of this work was to assess the effect of percutaneous coronary revascularization (PCR) on plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentration. BACKGROUND Left ventricular (LV) dysfunction is associated with increased plasma natriuretic peptide concentrations. The effect of ischemia resolution on plasma natriuretic peptide is not known. METHODS T...