The pleckstrin homology (PH) domain-containing protein Daughter of Sevenless (DOS) is an essential component of the Sevenless receptor tyrosine kinase (SEV) signaling cascade, which specifies R7 photoreceptor development in the Drosophila eye. Previous results have suggested that DOS becomes tyrosine phosphorylated during SEV signaling and collaborates with the protein tyrosine phosphatase CSW....

Maintaining genomic integrity during DNA replication is essential for stem cells. DNA replication origins are licensed by the MCM2-7 complexes, with most of them remaining dormant. Dormant origins (DOs) rescue replication fork stalling in S phase and ensure genome integrity. However, it is not known whether DOs exist and play important roles in any stem cell type. Here, we show that embryonic s...

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Estudos pirolíticos dos óleos vegetais das partes (endocarpo mais mesocarpo e epicarpo) do fruto da Macauba (Acrocomia sclerocarpa M.) foram realizados sob atmosfera de hélio usando-se um pirolisador de filamento modelo Girdel 75 -Py -1, conectado diretamente a um CG/EM. Os experimentos foram realizados em diferentes temperaturas e tempos de pirólise, para avaliar como estes parâmetros afetam o...

One of the most interesting aspects of amorphous semiconductor multilayers is their application in studying the interfaces between different a-Si:H based alloys, because of the great number of interfaces that a multilayer structure can contain. There are several magnitudes, such as the additional hydrogen content at interfaces [1,2] or the density of states (DOS) per interface [3-7] that can be...

A new aminoglycoside antibiotic, S-11-A, was isolated from the fermentation broth of the 2-deoxystreptamine negative (DOS-) mutant of Bacillus circulans S-11. The structure of S-11-A was elucidated as 1-deamino-1-hydroxyxylostasin, which contains an intermediate of DOS biosynthesis (S-11-P) and has resistance to some aminoglycoside-inactivating enzymes. This is the first finding of antibiotic p...