OBJECTIVES In the use of activated carbon beds as adsorbents for various types of organic vapor in respirator gas filters, water adsorption of the bed and test gas humidity are expected to alter the accuracy in the estimation of breakthrough data. There is increasing interest in the effects of moisture on estimation methods, and this study has investigated the effects with actual breakthrough d...

[1] Large rivers are major conduits for sediment and nutrient transport and play an important role in global biogeochemical cycles. While smaller rivers received attention in recent decades for hyporheic exchange and nutrient uptake, fewer studies have focused on the dynamics of surface storage zones in large rivers. We investigate transport dynamics in the St. Clair River, an international riv...

Cancer may soon become the leading disease-related cause of human death in many countries of the world. In the United States, cancer is projected to surpass cardiovascular disease as the major cause of death. Nevertheless, there is good news forthcoming with respect to emerging breakthrough drugs that demonstrate our increased understanding of cancer at the molecular level, a greater focus on m...

Many a science writer has fantasized about capping a story with the headline “Good News for Sick Mice!” One of the toughest struggles is deciding how to cover a story that has produced tantalizing, even amazing, results in laboratory animals but could well be a total bust by the time it gets to humans. That issue came up in early July, when Elan Pharmaceuticals, an Irish company with laboratori...

[1] Temporary storage of solutes in streams is often controlled by flow-induced uptake in hyporheic zones. This phenomenon accounts for the tails that are generally observed following the passage of a solute pulse, and such exchange is particularly important for the transport of reactive substances that can be subject to various biogeochemical processes in the subsurface. Advective pumping, ind...

The transport characteristics of two adhesion-deficient, indigenous groundwater strains, Comamonas sp. strain DA001 and Erwinia herbicola OYS2-A, were studied by using intact sediment cores (7 by 50 cm) from Oyster, Va. Both strains are gram-negative rods (1.10 by 0.56 and 1.56 by 0.46 microm, respectively) with strongly hydrophilic membranes and a slightly negative surface charge. The two stra...

The load phase in preparative Protein A capture steps is commonly not controlled in real-time. The load volume is generally based on an offline quantification of the monoclonal antibody (mAb) prior to loading and on a conservative column capacity determined by resin-life time studies. While this results in a reduced productivity in batch mode, the bottleneck of suitable real-time analytics has ...

the sources of groundwater pollution such as, industrial effluents, sewage and extensive farming have lead to agrochemical pollution. mathematical modeling helps to analyze the existing situation, allows forecasting, and to evaluate the effects of changes in the surrounding water quality. the present research has been focused mainly towards understanding the various processes affecting the tran...

Background. The precision and limitations of ventricular pacemapping as a method to localize the site of earliest breakthrough of ventricular tachycardia (VT) were investigated in a canine model of experimental myocardial infarction. Methods and Results. Forty-one episodes of VT induced in 10 animals were mapped using a standard grid of 64 endocardial and epicardial bipolar electrodes to determ...

Background. We have previously shown that 75% of individuals on antiretroviral therapy (ART) in a resource-limited setting who experienced virological breakthrough to >1000 copies/mL were resuppressed after an intensive adherence intervention. This study examines the long-term outcomes of this group in order to understand the impact of the adherence intervention over time. Methods. ART-naïve ad...