BACKGROUND Important differences in the contributions of certain exposures to the risks of ductal versus lobular breast carcinomas have been observed, but few studies have evaluated the relationships between established breast cancer risk factors and other histologic types. METHODS Information on family history of cancer and reproductive, hormonal, anthropometric, and lifestyle characteristic...

background: alteration in peripheral blood lymphocytes (pbls) is usually investigated to provide an evidence of the host immune responses to tumor antigens. the tumor infiltrating nk cells interact most closely with the tumor cells and more accurately reflect tumor host interactions. objective: to analyze peripheral blood and tumor associated natural killer (nk) cells in patients with breast ca...

BACKGROUND Paired-like homeodomain transcription factor 2 (PITX2) is another new marker in breast carcinoma since hypermethylation at P2 promoter of this gene was noted to be associated with poor prognosis. We investigated the expression of PITX2 protein using immunohistochemistry in invasive ductal carcinoma and its association with the established growth receptors such as estrogen receptor (E...

Breast cancer is the most common neoplasia as well as the main cause of cancer-related death among women, experiencing a 0.5% increase in incidence per year. The disease results from a series of mutations in the DNA development and repair genes. Approximately 50% of human carcinomas present mutations in the TP53 gene. Polymorphisms of TP53 include codon 72 containing either arginine (CGC) or pr...

CONTEXT Immunohistochemistry has an expanding role in mammary pathology that has been facilitated by a growing list of available antibodies and a better understanding of biology. OBJECTIVE To explore the key role of immunohistochemistry in guiding adjuvant therapy decisions and sentinel node staging in breast cancer, as well as the role of immunohistochemistry as an aid to distinguishing usua...

Invasive micropapillary carcinoma of the breast is of growing clinical significance. The purpose of this study was to identify the radiological imaging features for this type of breast carcinoma and the axillary lymph nodes. The study population consisted of 30 breast cancer patients (8 invasive micropapillary carcinomas and 22 other types of invasive ductal carcinoma). The breast lesions were ...

PURPOSE Mucins are members of the glycoprotein family expressed in benign and malignant epithelial cells. The aim of this study is to evaluate the relationships between the expression of mucins in breast ductal carcinoma and clinicopathologic parameters. METHODS We constructed tumor microarrays based on 240 cases of invasive ductal carcinoma and 40 cases of ductal carcinoma in situ (DCIS) usi...

background & objectives: anaplastic lymphoma kinase (alk) is a receptor tyrosine kinase involved in the genesis of several human cancers. alk was initially identified because of its involvement in anaplastic large cell lymphoma (alcl). alk is believed to foster tumorigenesis following activation by autocrine and/or paracrine growth loops. studies reveal that the presence of anti-alk antibod...

Classical biological control (the introduction of exotic natural enemies) is often advocated as a tool for managing invasive species. Here, we review the effectiveness of biocontrol and explore the factors that determine whether it is an appropriate response to the invasive species problem. Although there have been some successes, biocontrol is generally poorly evaluated and, in many cases, its...

1 Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, United States, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, United States, Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, United States, Department of Biochemistry and Molecular Biolog...