Background: Breast cancer is the most common female malignancy and the leading cause of cancer mortality in women worldwide. The human epidermal growth factor receptor2 (HER2) is a transmembrane tyrosine kinase receptor that is usually overexpressed in human breast cancers. Stable cell lines heterogeneously overexpressing HER2 are highly required as in vitro models for breast cancer research. T...

Breast cancer is the most common cancer type among women all over the world. Chemotherapy is the use of anticancer medicines for treating cancer but it has many side effects and cells may become resistant to these chemical medicines. Therefore, finding new compounds of natural origin could be a promising solution to this problem. The aim of the current study was to evaluate anticancer activity ...

cancer is a group of diseases characterized by uncontrolled proliferation of abnormal cells. because of the severe side effects and resistance to the traditional chemotherapeutic agents, the necessity for discovery of new anticancer drugs is a crucial topic. in the present study we synthesized new derivatives of 2-(4-fluorophenyl)- n -halophenylacetamide and assessed their cytotoxicity against ...

a new series of anti-cancer agents based on 1,2-diaryl-5,6-dihydropyrrolo[2,1-a]isoquinoline scaffold containing n,n-diethylamino ethoxy, piperidinyl ethoxy or morpholinyl ethoxy group at the para position of the c-2 phenyl ring were synthesized and their cytotoxic activities were assessed against several human cancer cell lines including mcf-7 (er positive breast cancer cell), mda-mb231 (er-ne...

This work aims at introducing some energy operators linked to Teager-Kaiser energy operator (TKEO) (Kaiser in On a simple algorithm to calculate the energy of a signal, pp 381–384, 1990), its associated higher order versions and expanding them to multidimensional signals. These operators are very useful for analysing oscillatory signals with time-varying amplitude and frequency (AM–FM). We firs...