BACKGROUND We have shown that intravenous adenosine in normal subjects does not cause bronchospasm, but causes dyspnea, most likely by an effect on vagal C fibers in the lungs [Burki et al. J Appl Physiol 2005; 98:180-5]. Since airways inflammation and bronchial hyperreactivity are features of asthma, it is possible that intravenous adenosine may be associated with an increased intensity of dys...

It has been suggested that osmolarity and/or nebulizer output may affect the protective effects of disodium cromoglycate (DSCG) in asthma. The aim of this study was to evaluate the influence of osmolarity of the DSCG solution on exercise-induced bronchospasm (EIB) in children with bronchial asthma. A jet nebulizer was used for DSCG inhalation in Study 1 and an ultrasonic nebulizer in Study 2. T...

The hypothesis that airway afferent nerve subtypes act synergistically to initiate reflex bronchospasm in guinea pigs was addressed. Laryngeal mucosal application of capsaicin or bradykinin or the epithelial lipoxygenase metabolite 15(S)-hydroxyeicosatetraenoic acid evoked slowly developing but pronounced and sustained increases in tracheal cholinergic tone in situ. These reflexes were reversed...

Bronchoconstriction has been reported in asthma and chronic obstructive pulmonary disease (COPD) patients after administration of some aqueous inhalation solutions. We investigated the incidence of this event during long-term clinical trials of tiotropium delivered via Respimat(®) Soft Mist™ Inhaler (SMI). We retrospectively analyzed pooled data from two identical Phase III clinical trials, in ...

Methods In this cross sectional study were included 115 asthmatic children and adolescents 9 to 19 years old and their mothers. For the children, asthma severity, PA level and exercise induced bronchospasm (EIB) were evaluated. The mothers were investigated on their beliefs about PA in non-asthmatic and asthmatic children, if they imposed restrictions to their children PA, perception of exercis...

The aim of the present study was to evaluate invitro and invivo antiasthmatic activity of ethanolic bark extract of Symplocos racemosa. For invitro study, isolated guinea pig ileum was used and dose response curve of histamine in plain Tyrode solution and in Tyrode solution containing 25 μg/ml ethanolic barks extract of Symplocos racemosa were performed. For invivo study histamine induced bronc...

After the introduction of anti-TNFα medication for treatment of autoimmune conditions, clinicians have investigated not only other possible uses for the drugs, but also less common side-effects and interactions with other pathologies. Despite some succes registered with Adalimumab as an antiinflammatory agent in severe asthma, there have been case reports of patients developing asthma or asthma...

Reports about anaphylactic and anaphylactoid reactions to rocuronium have increased recently. We report two new cases of documented grade III anaphylaxis, leading to death in one patient. The first case occurred in an 81-year-old ASA II woman scheduled for emergency abdominal surgery. Severe hypotension and tachycardia were observed after rocuronium, without bronchospasm. Neosynephrine allowed ...

We report a case of left pulmonary artery sling in a child who also had duodenal atresia. He was admitted for respiratory failure requiring prolonged respiratory support due to a bronchiolitis-like illness at two months of age. Diagnostic procedures confirmed the presence of left pulmonary artery sling. He had a corrective procedure which relieved the compression. However postoperatively he had...

Abstract Ascariasis is a common helminthic infection, particularly in the tropical countries. We describe case of eosinophilia who underwent coronary artery bypass graft (CABG) surgery. Postoperatively, he was found to have ascaris lumbricoides oral cavity. Timely detection and removal worm prevented possible complications such as airway obstruction, bronchospasm, lung collapse, or intestinal o...