نتایج جستجو برای: bruton
تعداد نتایج: 389 فیلتر نتایج به سال:
x-linked agammaglobulinemia (xla) is an immunodeficiency caused by mutations in the bruton tyrosine kinase (btk) gene. in order to identify the mutations in btk gene in iranian patients with antibody deficiency, 13 male patients with an xla phenotype from 11 unrelated families were enrolled as the subjects of investigation for btk mutation analysis using pcr-sscp followed by sequencing. five di...
Targeted therapy with inhibitors of cell signaling pathways and anti-apoptotic molecules significantly improved treatment chronic lymphocytic leukemia. Inhibitors Bruton?s tyrosine kinase bcl2 protein showed significant efficacy in either treatment-na?ve or relapsed/refractory patients poor risk factors. The majority respond to have durable remissions, but some them develop resistance, which le...
Disease Overview Waldenström macroglobulinemia (WM) is a lymphoplasmacytic lymphoma with immunoglobulin M (IgM) monoclonal protein. Clinical features include anemia, thrombocytopenia, hepatosplenomegaly, lymphadenopathy, and rarely hyperviscosity. Diagnosis Presence of IgM protein associated ?10% clonal cells in bone marrow confirms the diagnosis. The L265P mutation MYD88 detectable more than 9...
The recent description of a Lin(-)AA4.1(+)CD19(+)B220(Lo/-) B1-specified progenitor (B1P) population in adult marrow adds support for the argument that these unique B cells arise from a distinct lineage. However, the origins of B1P were not investigated and their developmental relationships to conventional B2 cells remain unclear. We now report that B1P development is IL-7Ralpha-dependent, and ...
X-linked agammaglobulinemia (XLA) is a primary immunodeficiency of the humoral compartment, due to a mutation in the Bruton tyrosine kinase (BTK) gene, characterized by a severe defect of circulating B cells and serum immunoglobulins. Recurrent infections are the main clinical manifestations; although they are especially due to encapsulated bacteria, a specific association with Campylobacter sp...
[PDF] [Full Text] [Abstract] , September, 15 2010; 588 (18): 3551-3566. J Physiol H. Zeanah and David S. Criswell Vitor A. Lira, Dana L. Brown, Ana K. Lira, Andreas N. Kavazis, Quinlyn A. Soltow, Elizabeth in skeletal muscle cells α Nitric oxide and AMPK cooperatively regulate PGC-1 [PDF] [Full Text] [Abstract] , November, 1 2010; 588 (21): 4275-4288. J Physiol Zhang, Masanobu Wada, Pasi Ta...
Signals through the B-cell antigen receptor (BCR) are important for the survival of chronic lymphocytic leukemia (CLL) cells. Therefore, factors that influence these signals have important pathophysiological roles in this disease. One key mediator of BCR signaling is protein kinase C beta (PKCbeta), which regulates the activation of I-kappaB kinases and the deactivation of Bruton tyrosine kinas...
The Bing-Neel syndrome is a rare neurological complication of Waldenström's Macroglobulinemia which results from a direct involvement of central nervous system by malignant lymphoplasmacytic cells. The clinical suspicion of Bing-Neel syndrome may be overlooked because neurologic symptoms are heterogeneous, nonspecific and sometimes underhand. A definitive diagnosis of Bing-Neel syndrome can be ...
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