MOTIVATION Gene finding in eukaryotic genomes is notoriously difficult to automate. The task is to design a work flow with a minimal set of tools that would reach state-of-the-art performance across a wide range of species. GeneMark-ET is a gene prediction tool that incorporates RNA-Seq data into unsupervised training and subsequently generates ab initio gene predictions. AUGUSTUS is a gene fin...

Nowadays, organizations face severe operational risks when executing their business processes. Some reasons are the ever more complex and dynamic business environment as well as the organic nature of business processes. Taking a risk perspective on the business process management (BPM) lifecycle has thus been recognized as an essential research stream. Despite profound knowledge on risk-aware B...

The white blood cell DNA of 36 cord blood samples with Hb Bart’s in the red blood cells was studied for a-globin gene deletions by hybridization of DNA fragments digested by the restriction endonucleases Eco RI, Hpa I. Bam HI, and Bgl II. All 16 DNA samples from cord blood with Hb Bart’s below 3% and no other abnormal hemoglobin had one a-globin gene deletion (athal2), except one which had two ...

Covarying phenotypic traits can limit natural selection’s ability to modify these traits. Most evolutionary studies on trait covariation use the comparative method to study complex traits of multicellular organisms. Simpler traits have the advantage of being amenable to experimental evolution. Here we study such a simple molecular system, the TEM-1 beta-lactamase protein, a promiscuous enzyme t...

Organizations strive to optimize their business processes in order to satisfy customer requirements and internal goals. A basic necessity in order to meet time and quality objectives is to monitor an organization’s business processes. Process monitoring makes their execution more transparent and allows to react to observed deviations with corrective actions. This paper focuses on monitoring pro...

Today’s enterprises demand a high degree of compliance in their business processes to meet diverse regulations and legislations. Several industrial studies have shown that compliance management is a daunting task, and organizations are still struggling and spending billions of dollars annually to ensure and prove their compliance. In this demonstration, we present, BP-MaaS (Business Process Mon...

EXECUTIVE SUMMARY Electronic services have become a critical force in service oriented economies introducing new paradigms like connected governance, ubiquitous and ambient public services, knowledge-based administration, and participatory budgeting. The success of e-Government integration requires the modernization of current governmental processes and services under three different perspectiv...

Traditionally, human intervention is required to monitor a business process. Operators notify when manual activities are executed, and manually restart the monitoring whenever the process is not executed as expected. This paper presents mArtifact, an artifact-driven process monitoring platform. mArtifact uses the E-GSM artifact-centric language to represent the process. This way, when a violati...

Contract monitoring is carried out to ensure the Quality of Services (QoS) attributes and levels specified in an electronic contract throughout a business process enactment. This paper proposes an approach to improve QoS monitoring based on the aspect-oriented paradigm. Monitoring concerns are encapsulated into aspects to be executed when specific process points are reached. Differently from ot...