The discovery that lithium treatment at blastula stages can induce axis formation suggested that it might act by respecifying the cytoplasmic rearrangement-generated dorsoventral pattern, so that ventral cells behave like their dorsal counterparts. We have studied the effects of Li treatment on the spatial layout of the cell-group movements of gastrulation to see whether this is the case. We fi...

Considerable focus has been devoted to how much antipsychotic is appropriate for optimal clinical response, although how often antipsychotics need to be administered is also less than clear. Clinicians are aware of the increased risk of relapse related to antipsychotic nonadherence/discontinuation, and current practice dictates continuous antipsychotic exposure with the goal of achieving steady...

THE events of the past 2 yr since the initial controversial publication by Mangano et al. regarding the effect of aprotinin on renal failure and mortality have been of great interest to the anesthesiology community. In this issue of ANESTHESIOLOGY, Dietrich et al. test the hypothesis that any potential nephrotoxic effect of aprotinin (Bayer Healthcare Inc., Toronto, Ontario, Canada) is dose dep...