Preparation of 4-benzyl-2-substituted phthalazin-1-one derivatives 2-8 is reported. Condensation of 4-benzyl-1-chlorophthalazine (9) with a series of different nucleophiles gave 4-benzylphthalazin-1-ylamino derivatives (10-13 and 16) and 4-amino-2-[N'-(4-benzylphthalazin-1-yl)-hydrazino]-6-arylpyrimidine-5-carbonitriles (14a,b). Interaction of 9 with ambident anions was also studied. 5-Benzyl-6...

BACKGROUND AND THE PURPOSE OF THE STUDY Hospital-acquired methicillin-resistant Staphylococcus aureus (MRSA) has been a major problem worldwide in chemotherapy of infection disease. This study was designed to assess the enhancing effects of a new group of dihydropyridine-3,5dicarboxamides, in combination with cloxacillin with distinctly different mechanisms of action against MRSAs. MATERIAL A...

A simple, rapid "high-performance" liquid-chromatographic procedure is presented for the determination of aminoglutethimide in plasma. After precipitation of the protein with acetonitrile, an aliquot of the supernate is injected directly onto a radially compressed, reversed-phase column. The aminoglutethimide is isocratically eluted with a mobile phase of acetonitrile/water/tert-butyl ammonium ...

Tetra-n-butyl ammonium bromide (TBAB) was found to be an efficient phase-transfer catalyst for the synthesis of pyrido[2,3-d]pyrimidines by one-pot reaction of 6-aminouracils, aromatic aldehydes, and malononitrile or ethyl cyanoacetate in water under ultrasonic irradiation. The advantages of this method are the use of an inexpensive and readily available catalyst, short reaction time, easy work...

In the title compound, (C(16)H(36)N)[Fe(C(12)H(8)N(3)O(2))(CN)(3)]·2H(2)O, the tetra-n-butyl-ammonium ion has a tetra-hedral configuration around the N atom, while the Fe(III) atom of the tricyanido[N-(2-pyridyl-carbon-yl)pyridine-2-carboximidato]iron(III) anion adopts a distorted octa-hedral geometry. O-H⋯O and O-H⋯N hydrogen bonds link the components in the crystal structure.

The cotton root-rot disease, caused by the fungus Phymatotrichum omnivorum (Shear) Duggar, has been the subject of extended investigations since its discovery by Pammel {5) ^ in Texas in 1888. Although much knowledge has been obtained in regard to the ecolo^ of the fungus, its life history, morphology, and some of its physiological aspects, there is as yet little known regarding the growth beha...