Objective: Inhibition of lipid metabolism in breast cancer has been suggested as an effective approach for cancer therapy. Saffron-derived crocetin (Crt) and crocin (Cro) with the known anticancer activity, have shown hypolipidemic effect in diabetes and atherosclerosis. Here, we investigated the effect of Crt/Cro on lipid content in breast cancer. Materials and M...

BACKGROUND Metabolic diseases in China have been on the rise in recent decades, partially due to reduced cereal consumption and excessive intake of low glycemic index (GI) foods such as meat and oil. Although the relationship between dietary glycemic load (GL) and various metabolic diseases has been extensively studied worldwide, it is unclear whether dietary GL is related to blood lipid levels...

BACKGROUND/AIM Cardiovascular morbidity and mortality are markedly increased in chronic renal failure (CRF). The aim of this study was to evaluate lipid parameters and bioindices in patients with different stages of CRF. METHODS In 46 hemodialysed (HD), 50 CRF patients with II, III and IV stage of CRF (non-HD) and 48 control subjects triglycerides (TG), total cholesterol (C), HDL-C, urea, cre...

BACKGROUND & OBJECTIVES Prevalence of insulin resistance and associated dyslipidaemia [high triglyceride (TG) and low high-density lipoprotein cholesterol (HDL-C) concentrations] are increased in South Asian individuals; likely contributing to their increased risk of type-2 diabetes and cardiovascular disease. The plasma concentration ratio of TG/HDL-C has been proposed as a simple way to ident...

Background: Climate change is a serious threat to human wellbeing and development. Global reduction of meat intake key addressing climate other modern sustainability challenges. Plant-based mycoprotein-based substitutes are predicted play role in the intake; however, their impact on health unclear. The main objective this meta-analysis was assess short-term effects important cardiometabolic bio...

The antidiabetic effect of various extracts of Desmodium gangeticum (D. gangeticum) was evaluated on normal and streptozotocin (STZ)-nicotinamide induced type-2 diabetic animals. Type-2 diabetes was induced in Wistar albino rats of either sex by the administration of STZ-nicotinamide (40, 110 mg/kg b.w., respectively) intraperitoneally. D. gangeticum (100 mg/kg b.w.) extracts in different solve...

The cardioprotective effect of consuming cruciferous vegetables may be attributed to a number of unique indole-based compounds. We investigated the potential role and mechanism of action of an indole-based compound, indole-3-carbinol (I-3-C), on apolipoprotein B-100 (apoB) production using HepG2 cells. I-3-C reduced apoB secretion into the media dose dependently by 56% at 100 micromol/L. Relati...