نتایج جستجو برای: c1
تعداد نتایج: 16278 فیلتر نتایج به سال:
INTRODUCTION Hereditary angioedema due to C1-inhibitor deficiency (C1-INH-HAE type I) or dysfunction (C1-INH-HAE type II) is a rare disease characterized by recurrent episodes of edema with an estimated frequency of 1:50,000 in the global population without racial or gender differences. In this study we present the results of a nationwide survey of C1-INH-HAE patients referring to 17 Italian ce...
In septic shock, hypotension, disseminated intravascular coagulation, and neutrophil activation are related to the activation of the blood coagulation contact system. This study evaluates in dogs the effect of the C1-esterase inhibitor (C1-INH), a main inhibitor of the blood coagulation contact system, on the cardiovascular and respiratory dysfunction associated with endotoxic shock. Two groups...
severe abdominal edema; edema of face, neck, or lips and severe edema of the extremities and trunk. Clinical and laboratory data were entered into the Hungarian HAE Registry. Results: 152 attacks out of 1392 experienced by 42 patients were treated with C1-INH concentrate (28% of attacks at home and 72% at the clinic). The distribution of C1-INH-treated attacks by location was as follows: 38% su...
BACKGROUND Hereditary angioedema is a rare autosomal dominantly inherited immunodeficiency disorder characterized by potentially life-threatening angioedema attacks. OBJECTIVE We aimed to investigate the clinical and genetic features of a family with angioedema attacks. METHODS The medical history, clinical features and C1-INH gene mutation of a Turkish family were investigated and outcomes...
The complement system is an important antimicrobial and inflammation-generating component of the innate immune system. The classical pathway of complement is activated upon binding of the 774-kDa C1 complex, consisting of the recognition molecule C1q and the tetrameric protease complex C1r2s2, to a variety of activators presenting specific molecular patterns such as IgG- and IgM-containing immu...
و غیر ?? پایا، ارگودی ?? فشرده، هر اندازه احتمال ?? از منیفلد ریمان c1+ کنیم برای هر دیفئومورفیسم
In spite of antibiotic treatment, pneumococcal meningitis continues to be associated with significant morbidity and mortality. The complement system is a key component of innate immunity against invading pathogens. However, activation of complement is also involved in tissue damage, and complement inhibition by C1 inhibitor (C1-inh) is beneficial in animal models of endotoxemia and sepsis. In t...
We first introduce a multivariate probit model for ordinal responses as implemented in R package mprobit. As before, we have n independent observations (Yi, X ′ i) with Yi = 0 or 1 as disease status andX ′ i = (Xi1, ..., Xik) as genotypes at k SNPs for subject i, i = 1, ..., n. In addition, we have some possible covariates A. We assume that there is a Latent Gaussian variable Z ′ i = (Zi1, ...,...
We describe a practical model-based testing tool developed at Microsoft Research called Spec Explorer. Spec Explorer enables modeling and automatic testing of concurrent object-oriented systems. These systems take inputs as well as provide outputs in form of spontaneous reactions, where inputs and outputs can be arbitrary data types, including objects. Spec Explorer is being used daily by sever...
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