The effects of folinic acid on amethopterin-induced inhibition of growth, purine nucleotide biosynthesis, and DNA thymine formation were measured in Ehrlich ascites cells in vivo. Folinic acid prevented the amethopterin-induced prolongation of survival time of tumor-bearing mice at folinic acid levels which caused complete reversal of the inhibition of glycine-2-C14 incorporation into purines b...

The fatty acids of 18 strains of Bordetella avium, 3 strains of Alcaligenes faecalis, 5 strains of Bordetella bronchiseptica, and 12 strains of a B. avium-like organism were examined by gas chromatography-mass spectrometry. The presence of a significant amount of the acid 2-OH C14:0 characterized B. avium and the B. avium-like organism. B. avium and the B. avium-like organism differed in their ...

TAN-1511 analogues were synthesized and their effects on the proliferation of bone marrow cells were examined. To exert potent activity the following conditions are necessary: the configuration of the 2-amino-6,7-dihydroxy-4-thiaheptanoic acid moiety must be (2R,6R), long chain acyl groups (C14 to C18) must be bound to both hydroxyl groups, the amino group must be free or acylated with the long...

Much information has been published on the relationship of lipides to tumorigenesis (17), but most of the work has been concerned primarily with the more quantitative aspects of lipides in tumors and in the tissues of tumor-bearing ani mals. Investigations on the course of lipide bio genesis have been few. In a continuation of earlier work in this laboratory with normal animals (23), it seemed ...

succinate, while ?Ig+, AMP, and DPN+ were required for the oxidation of citrate. 2. Pyruvate-2-C14 and acetate-2-C14 were metabolized by the mitochondria. 3. The absorption of water by the endosperm tissue was accompanied by the activation of the Krebs cycle enzyme system. 4. The capacity of mitochondrial particles to oxidize succinate decreased as the embryos germinated; their ability to oxidi...

background: previous studies have shown that morphine consumption during pregnancy may cause delay or defect of embryo development or abnormal nervous system function in the human and animal models. in the present study, the highest density of morphine accumulation in the central nervous system of rat embryos was evaluated using c14‑morphine. methods: female wistar rats (w 170‑200 g) used and w...

succinate, while ?Ig+, AMP, and DPN+ were required for the oxidation of citrate. 2. Pyruvate-2-C14 and acetate-2-C14 were metabolized by the mitochondria. 3. The absorption of water by the endosperm tissue was accompanied by the activation of the Krebs cycle enzyme system. 4. The capacity of mitochondrial particles to oxidize succinate decreased as the embryos germinated; their ability to oxidi...