One-pot, four-component procedure for the synthesis of a small library of new chiral spiro- oxindolopyrrolidines with high regio-, diastereo- (>99:1 dr), and enantioselectivity (up to 80% ee) is described. In this process, the regio- and stereochemical 1,3-dipolar cycloaddition of azomethine ylides, which were generated insitu by the reaction of isatin derivatives and sarcosin,with optically ac...

Due to the growing concern about human health effects of ultraviolet (UV) radiation, the use of UV filters has increased in recent decades. Unfortunately, some common UV filters are bioaccumulated in aquatic organisms and show a potential for estrogenic activity. The aim of the present study is to determine the presence of some UV filters in the coastal waters of six beaches around Gran Canaria...

A triterpene saponoside (LTS-4) isolated from the underground parts of Lysimachia thyrsiflora L. was defined as 3-O-{beta-D-xylopyranosyl-(1 --> 2)-beta-D-glucopyranosyl-(1 --> 4)-[beta-D-glucopyranosyl-(1 --> 2)]-alpha-L-arabinopyranosyl}-cyclamiretin A. Structure assignment was performed on the basis of spectroscopic data including homo- and heteronuclear 1D and 2D NMR (COSY, TOCSY, NOESY, HE...

In this work, we carried out the design and synthesis of new chimeric compounds from natural cytotoxic chalcone 2′,4′-dihydroxychalcone (2′,4′-DHC, A) in combination with cinnamic acids. For purpose, a descriptive predictive quantitative structure–activity relationship (QSAR) model was developed to study compounds’ anti-cancer activities against human breast cancer MCF-7, relying on presence or...

The aim of this study was to prepare solid lipid microspheres (SLM) of octyl methoxy cinnamate (2-ethylhexyl-p-methoxy cinnamate; OMC) to achieve controlled release, decrease penetration of this UV absorber from skin and improve its photostability. The influence of the carrier on the rate of release was studied in vitro with a cellulose acetate membrane and in vivo from excised rat skin with Fr...

Single chain bolaamphiphile containing cinnamyl moiety [4鄄(棕鄄hydroxydecanyloxy) (棕鄄hydroxydecanyl) cinnamate, abr. HDC] was designed and synthesized. The photodimerization of the HDC molecules induced by UV light was the first time realized in organic solutions. The dimerized HDC was separated and formed spherical vesicles in 20% ethanol/water mixed solvents. The solvents忆 dielectric constants ...

The self-assembly and molecular packing mode of a novel, unsymmetrical bolaamphiphile, sodium 4-(6-hydroxyhexyloxy) cinnamate (SHHC) was studied. Tube-like structures were obtained in SHHC aqueous solution at pH 9.2. Upon UV irradiation, the SHHC molecules in the system were found to undergo four-center-type photocyclodimerization and photoisomerization. The combination of IR, XRD and Zeta pote...

Cinnamate-functionalised organic green emissive molecules can be UV-cured to give physically stable polymer films for use in white light hybrid LEDs.