Cd 2+ a heavy metal accumulates in the body and has a very long biological half-life (10–30 years) in humans. Environmental cadmium contamination occurs through industries related to batteries, coatings, electroplating, alloys, plastics, glasses, ceramics, enamels and artists’ colors, zinc, copper, lead, and iron ores treatment, coal and oil burning power plants, weathering of parent rocks etc....

BACKGROUND Cadmium is a heavy metal found naturally in the environment that has been associated with negative health outcomes. The present study examines levels of blood cadmium (BCd), urinary cadmium (UCd), and the main sources of cadmium exposure among Canadians aged 20 to 79. DATA AND METHODS The data are from cycles 1 (2007 to 2009) and 2 (2009 to 2011) of the Canadian Health Measures Sur...

Cadmium is known to exert toxic effects on multiple organs, including the testes. To determine if alpha-tocopherol, an antioxidant, could protect testicular tissues and spermatogenesis from the toxic effects of cadmium, six-week old male Sprague-Dawley rats were randomized to receive cadmium at doses of 0 (control), 1, 2, 4 or 8 mg/kg by the intraperitoneal route (Group A) or alpha-tocopherol f...

A study on the general population from both cadmium-polluted and control areas and on cadmium alloy workers indicates that beta 2-MG in urine is very closely correlated with aging, but it indicates an association with cadmium exposure. However, the age factor is stronger than cadmium exposre in both polluted and control areas among persons without clinical proteinuria. On the other hand, cadmiu...

We examined the effects of cadmium on the bcl-2 family of proteins--bcl-2, bax, bad, and bcl-xS/L--in cadmium-induced cytotoxicity. Addition of 10 microM cadmium to cultured porcine kidney LLC-PK(1) cells caused apoptosis. Western blot analyses revealed that cadmium markedly increased endogenous bcl-2 protein (to 3-4 times the level in wild-type cells) earlier than metallothionein induction, bu...

Cadmium is a well recognized environmental pollutant with diverse toxicity in various organs of human and animals (IARC, 1993). Prolong cadmium exposures can cause lung fibrosis, kidney tubular dysfunction, hypertension, osteoporosis, cancer, etc. (Peters et al., 1986; Patra et al., 2011). The common sources of cadmium are combustion of coal, mining, smelters and contaminated phosphate fertiliz...

Nurol Arik, Hacettepe Hastanesi Nefroloji Bölümü, TR-06100 Hacettepe-Ankara (Turkey) Dear Sir, There has been some controversy regarding the nature and importance of the effect of cadmium on hypertension in both humans and experimental animals [1-3]. Besides, the association between elevated blood cadmium and smoking habits is widely accepted [4]. In order to determine the relationship of cadmi...

Oysters from the north-west coast of Canada contain high levels of cadmium, a toxic metal, in amounts that exceed food safety guidelines for international markets. A first required step to determine the sources of cadmium is to identify possible spatial and temporal trends in the accumulation of cadmium by the oyster. To meet this objective, rather than sample wild and cultured oysters of unkno...

Chronic exposures to cadmium compounds are carcinogenic. It was hypothesized that the development of resistance to cadmium may drive carcinogenesis. This is achieved by selection of resistant cells in which the apoptotic response is significantly attenuated. The induction of cadmium resistance in rat lung epithelial cells (LEC) was used to explore the mechanisms of cadmium-induced adaptation an...