colorectal cancer (crc) is a third most common epithelial carcinoma. crc is known to develop from the early precancerous lesion to full blown malignancy via definite phases due to cumulative mutations and aberrant methylation of number of genes. the use of serum biomarkers that is non-invasive to discriminate cancer patients from healthy persons will prove to be an important tool to improve the...

it has been observed that lung cancer either non-small cell or small cell is responsible for eye metastases. this form of metastases in several cases was the first manifestation of the disease and further investigation led to the diagnosis of the underlying malignancy. both types of lung cancer are equally responsible for this demonstration. furthermore; both chemotherapy and tyrosine kinase in...

the main obstacle facing cancer preventive strategies worldwide is a lack of well conducted epidemiological studies to guide local and international efforts for disease control. in lebanon, long due political strain has added yet another obstacle to the development of methodologies aiming to collect data on cancer epidemiology. however, through several efforts dated from the 1960s the picture i...

Oral Cancer is one of the leading causes deaths in India. Despite growing innovations and trends field oral cancer diagnosis management, prevalence rate deadly disease keeps escalating. a debilitating disease, numerous research activities are being pursued worldwide to combat this deleterious process. Nanotechnology very diverse that has revolutionized industry setting new management cancer. He...

new cancer therapies with novel mechanisms and functions are needed to treat patients with different cancers. virotherapy is a good scenario for such treatment. the advantages of virotherapy include the potential lack of cross resistance with standard therapies and the ability to cause tumor destruction by numerous mechanisms. oncolytic virus not only possesses unique mechanisms of action that ...

Background: Prostate cancer is currently the third malignant disease in Iran and fifth common cancer worldwide. The aim of this study was to determine the expression of GPRC6A, E.cadherin, and ZEB1 genes in prostate cancer in comparison with benign tumor. Since early detection of cancer plays an important role in treatment, this study aims to identify the role of GPRC6A, E.cadherin and ZEB1 gen...

salivary diagnostics has fascinated many researcheres and has been tested as a valuable tool in the diagnosis of many systemic conditions and for drug monitoring. advances in the field of molecular biology, salivary genomics and proteomics have led to the discovery of new molecular markers for oral cancer diagnosis, therapeutics and prognosis. oral cancer is a potentially fatal disease and the ...

esophagus cancer is the eighth most common cancer worldwide and particularly high in an area extending from the southern border of the caspian sea in iran across central asia to china. since information about this mysterious disease is poor, proteomics may be solving this enigma. altering gene expression in cancer cell is a remarkable indicator can be detected by proteomics techniques and bioin...

background: chronic inflammation and dys-regulation of the immune system mechanisms are now well established as primary triggers of gastric cancer and peptic ulcer disease. galectin-9 (gal-9) is a member of the galectin family and known as an inducer of cell aggregation, adhesion and apoptosis. gal-9 interaction with its main ligand t-cell immunoglobulin and mucin domain protein-3 (tim-3) leads...

Background: Micro-Ribonocellic Acids (miRNA) are non-coding nucleic acids that are evolutionally protected and have a length of 24-20 nucleotides. MiRNAs control the expression of genes after transcription by mRNA degradation or translation inhibition. By blocking the oncogenic miRNAs and creating the necessary and functional miRNAs (tumor suppressor), these small regulatory RNAs can have thera...