background there are hoarding documents for the biological importance of cyclooxygenase-2 (cox-2) in pancreatic carcinogenesis. we aimed to thoroughly investigate the dna sequence variations of whole cox-2 exons in a large case-control study of pancreatic cancer by direct sequencing.   methods the entire exonic regions of cox-2 including 10 exons were sequenced in the germline dna of 96 patient...

Background: The increased prevalence of cancer in children influences the family as the main child caregiver. Regarding the spiritual dimension for increasing the life quality of parents and its effect on the management of the conditions induced by the disease, the goal of this study was to determine the strategy of care in parents of cancer children. Materials and Methods: This study was perf...

abstract breast cancer is a multifactorial disease. benign breast disease (bbd) is one of the most important risk factors for breast cancer. the etiology of bbd is unknown. it is divided into nonproliferative and proliferative diseases. the selection of studies will be based on titles, abstract screening, inclusion and exclusion criteria, and quality assessment. previous studies have shown that...

a 48-year-old woman was admitted to the emergency department with complaints of typical chest pain, cold sweat, and dyspnea of 24 hours’ duration. she had a history of hypertension, hyperlipidemia, and diabetes mellitus for many years. on admission, her electrocardiogram (ecg) revealed normal sinus rhythm and dynamic t inversion in the precordial leads. her enzyme levels were normal. transthora...

CLINICAL PRESENTATIONA 44-year-old lady came to a dermatology clinic due to an asymptomatic, hyperpigmented plaque on her right thigh since 4 months ago. On physical exam, hypertrichosis on the lesion was notable (Figure 1). Rubbing the lesion resulted in erythema and edema of the lesion. She had no systemic disease and her family history was unremarkable.

There is an obesity epidemic in the Western World. Currently one in four adults is obese and three in ten children in the UK is overweight or obese [1]. The UK Foresight Study [2] predicts that if nothing is done, this figure will rise to five in ten (50%) in women by 2050. The endocrine changes induced by obesity lead to an increased incidence of endometrial cancer. The majority of women with ...

Figure 1. A. Basic signal-to-time patterns determined within the prostate in DCE-MRI studies of a patient with prostate cancer and their corresponding weights displayed as heat maps in one slice of the prostate. B. Corresponding T2-w, showing areas of hypointensity, suspicious for cancer. The same image is overlaid with the map of the tumor pattern. Figure 2. A. Two T2-w axial views from patien...