Introduction : The process of protein synthesis is a vital for all kingdoms life. ribosome ribonucleoprotein complex that reads the genetic code, from messenger RNA (mRNA) to produce proteins and tightly regulate ensure cells growth. fact numerous diseases are caused by defect during biogenesis important understand this pathway. Materials methods We have analyzed literature its links with diffe...

Gene therapy has held promise to correct various disease processes. Prostate cancer represents the second leading cause of cancer death in American men. A number of clinical trials involving gene therapy for the treatment of prostate cancer have been reported. The ability to efficiently transduce tumors with effective levels of therapeutic genes has been identified as a fundamental barrier to e...

Cancer is a disease with extraordinary clinical significance, much of medical research being devoted to it. Innumerable factors are relevant in fully understanding cancer but the epigenetic aspect stands out. Epigenetics study changes, often germ-line, genome affecting gene expression by silencing certain genes and modifying expression. The three primary mechanisms for changes DNA methylation, ...

background: exposure to endogenous hormones such as estrogen is known as a lifetime breast cancer (bc) risk factor. polymorphisms in genes that are involved in the steroidogenic process, such as cytochrome p450c17alpha ( cyp17) , affect individuals’ susceptibility to bc. in iran, the highest incident of bc is among young women. this study aimed to find prevalence of single nucleotide polymorphi...

prostate cancer is the second most common cancer in men. in spite of on-going researches in this filed, the specific causes of prostate cancer are so far unknown. in this study, we used two methods of gene set analysis to improve the biological interpretation of the observed expression patterns in prostate cancer. the gene set analysis is a computational method to discover gene sets whose expre...

Abstract Background Immunotherapy is a revolutionary strategy in cancer therapy, but the resistance of which one important challenges. Detecting regulation immune cells and biomarkers concerning checkpoint blockade (ICB) therapy great significance. Methods Here, we firstly constructed networks for 11 cell clusters by integrating biological pathway data single sequencing metastatic melanoma with...