BACKGROUND Candida albicans (C. albicans) has several virulence factors, in particular heat shock protein 90 (Hsp90), which is expressed by Hsp90 gene. The purposes of this study were to assess the expression of Hsp90 gene in clinical and control isolates of C. albicans obtained from different geographical regions (Malaysia and Iran), different temperatures (25°C, 37°C and 42°C) and mice with c...

background and purpose: oropharyngeal candidiasis (opc) and antifungal drug resistance are major health concerns in patients with human immunodeficiency virus (hiv). the increased reports of antifungal resistance and expanding drug therapy options prompted the determination of antifungal susceptibility profile. the present study was performed to determine the antifungal susceptibility of candid...

BACKGROUND Otomycosis is a superficial fungal infection often involves the pinna and external auditory canal. It is a pathologic condition, with Candida and Aspergillus, the most common fungal species. It is common worldwide but more prevalent in tropical and subtropical countries. OBJECTIVES The aim of this study was to determine the etiologic agents and local epidemiologic pattern of otomyc...

background and aims: candida albicans is the most common cause of vulvovaginitis candidiasis that is the most common vaginitis in human. it is estimated that more than 90% of these infections are caused by candida albicans. medical treatment for these infections is carried out with chemotherapeutic drugs such as azoles. the increasing resistance of c. albicans to the azoles as well as their pro...

Abstract Background: Candidemia is the main cause of fungal nosocomial bloodstream infections and is related to meaningful mortality specially, in pediatrics. Mortality rate range from 5% to 71%, and it can reach as high as 81%. Delays in beginning of treatment have also been linked to intensified mortality. The epidemiology of Candida infection is changing from region to region. Regiona...

OBJECTIVES To review the epidemiology of invasive Candida infections in a single center in Saudi Arabia over a subsequent 10-year period. METHODS This retrospective study was carried out in a single center in Saudi Arabia over a 10-year period. Records of all patients with invasive Candida infections (ICI) over the period from January 2003 to December 2012 were reviewed. Mann-Whitney U test w...

Although normally commensals in humans, Candida albicans, Candida tropicalis, Candida parapsilosis, Candida glabrata, and Candida krusei are capable of causing opportunistic infections in individuals with altered physiological and/or immunological responses. These fungal species are linked with a variety of infections, including oral, vaginal, gastrointestinal, and systemic infections, with C. ...

keywords: Candiduria, Non albicans Candida, Antifungal susceptibility testing ABSTRACT Objective: The incidence of Candida has been on rise worldwide. Urinary tract infections [UTIs] as a result of Candida species are becoming, common in hospitalised patients. Clinicians face dilemma in differentiating colonization from true candiduria. The species identification of Candida is important, as non...

The antimicrobial property of volatile aromatic oils from medicinal as well as other edible plants has been recognized since antiquity. Candida species are an important cause of opportunistic infections in the oral cavity of immunocompromised patients and vaginal candidiasis. The antifungal activity of the essential oil of Pimento dioica (allspice oil) was investigated against 75 clinical isola...

Candida albicans is an opportunistic human pathogen, which colonizes at several anatomically distinct sites including skin, oral, gastrointestinal tract, and vagina. How harmless commensal C. albicans become a human pathogen when opportunity comes is not clear. This review will focus on the molecular dissection of virulence factors of C. albicans, including adhesion, proteinases secretion, hyph...