The mechanism whereby cAMP stimulates Cl(-) flux through CFTR ion channels in secretory epithelia remains controversial. It is generally accepted that phosphorylation by cAMP-dependent protein kinase increases the open probability of the CFTR channel. A more controversial hypothesis is that cAMP triggers the translocation of CFTR from an intracellular pool to the cell surface. We have monitored...

This paper presents a biosensor-CMOS platform for measuring the capacitive coupling of biorecognition elements. The biosensor is designed, fabricated, and tested for the detection and quantification of a protein that reveals the presence of early-stage cancer. For the first time, the spermidine/spermine N1 acetyltransferase (SSAT) enzyme has been screened and quantified on the surface of a capa...

Measurement of the magnitude and kinetics of exocytosis from intact epithelia has historically been difficult. Using well-differentiated cultures of human bronchial epithelial cells, we describe the use of transepithelial impedance analysis to enable the real-time quantification of mucin secretagogue-induced changes in membrane capacitance (surface area) and conductance. ATPgammaS, UTP, ionomyc...

Conventional Flux Compression Generators (FCG's) are used to generate high power DC pulses. A new kind of (FCG's) with series capacitance called Capacitive Flux Compression Generator (CFCG) will be introduced and explained in this paper. This new kind is used to generate modulated high power pulses. There are some problems to establish a capacitance in high power and high frequency applications...

RF reflectometry offers a fast and sensitive method for charge sensing spin readout in gated quantum dots. We focus this work on the implementation of accumulation-mode gate-defined dots, where large parasitic capacitance poses challenge. describe test two methods mitigating effect capacitance, one by on-chip modifications second off-chip changes. demonstrate that these enable high-performance ...

A measurement technique for a commercial four-terminal (4 T) air-dielectric capacitance standard set (Keysight 16380A) frequencies from 1 kHz up to 13 MHz was developed the accurate calibration of impedance analyzers. The consists at using precision bridge, seven measurements one-port driving point (DPI) over 30 vector network analyzer (VNA), and various numerical calculation procedures parasit...

Reduction of VO2 resistance by nearly 3 orders of magnitude through H2 treatment was reported for supercapacitor application. A specific discharge capacitance of 300 F g(-1) and a specific energy density of 17 W h kg(-1) at a rate of 1 A g(-1) are demonstrated with long-term cycling stability, which is 4 times higher than untreated samples.

Electrical capacitance tomography (ECT) is a technique invented in the 1980’s to determine material distribution in the interior of an enclosed environment by means of external capacitance measurements (Huang et al., 1989a, 1992b). In a typical ECT system, 8 to 16 electrodes (Yang, 2010) are symmetrically mounted inside or outside a cylindrical container, as illustrated in Figure 1. During the ...

An 8-electrode capacitance tomography (ECT) sensor was built and used to measure moisture content (MC) and mass flow of pine chip flows. The device was capable of directly measuring total water quantity in a sample but was sensitive to both dry matter and moisture, and therefore required a second measurement of mass flow to calculate MC. Two means of calculating the mass flow were used: the fir...

Dynamic measurements of exocytosis have been difficult to perform in intact epithelial monolayers. We have designed a system that estimates with +/-1% accuracy (99% confidence) the total membrane capacitance of monolayers represented by a lumped model. This impedance measurement and analysis system operates through a conventional transepithelial electrophysiology clamp, performing all signal me...