We report a case of carbamazepine withdrawal syndrome following in utero exposure to carbamazepine related to a pharmacogenetic predisposition factor. The infant was born at 37 1/7 weeks' gestation by cesarean section to a mother treated for epilepsy with carbamazepine. One hour and thirty minutes after birth, the infant presented a respiratory distress with severe oxygen desaturation requiring...

The present study was designed to investigate the putative effect of neurosteroid modulation on global ischaemia-reperfusion-induced cerebral injury in mice. Bilateral carotid artery occlusion followed by reperfusion, produced a significant rise in cerebral infarct size along with impairment of grip strength and motor coordination in Swiss albino mice. Administration of carbamazepine (16 mg/kg,...

A 73-year-old woman outpatient with mild cognitive impairment, parasomnia and depressive state with musical hallucinations failed to respond to 400 mg/day of valproate. Once she was admitted to a university hospital, her musical hallucinations partially responded to 1 mg/day of clonazepam and sufficiently improved on 100 mg/day of carbamazepine. Two months after discharge, however, her musical ...

We report the case of a 61-year-old man with schizophrenia who was treated with carbamazepine, in whom electrocardiography showed transient Brugada-type ST elevation. He had been hospitalized our hospital's Department of Psychiatry and had been diagnosed with pneumonia. On the following day, electrocardiography showed coved-type ST elevation in the right precordial leads and a blood examination...

A copper(II) functionalized hierarchical faujasite zeolite/activated carbon composite adsorbent (Cu-CFAU) was prepared in an attempt to develop a platform for the effective removal of contaminants emerging concern (CECs: caffeine, carbamazepine, naproxen, and metabolites clofibric acid, 10,11-epoxy-carbamazepine, o-desmethyl-naproxen, paraxanthine, salicylic acid) from water at ambient conditio...

Submerged membrane bioreactors (SMBR) are widely known for their advantages in the field of wastewater treatment. However, despite significant technological advances recent decades, fouling remains one major concerns its efficient application. Recent studies, carried out with synthetic wastewater, show that integration electrochemical processes as electrocoagulation membranes technologies provi...

For the first time, high energy VUV photons and generation of O3 by (V)UV lamps were applied together for removal active pharmaceutical ingredients (APIs) from biologically treated wastewater (BTWW) in pilot-scale. The core pilot container unit was a photoreactor assembly consisting six photoreactors, each containing low-pressure Hg lamp (UV dose 1.2 J/cm2 6.6 at 185 nm 254 nm, respectively). B...

This study presents findings on an assessment of the effect of continuous and batch feeding strategies on the removal of selected pharmaceuticals from synthetic wastewater. Six mesocosm-scale constructed wetlands, including three horizontal subsurface flow constructed wetlands and three sand filters, were set up at the campus of Nanyang Technological University, Singapore. The findings showed t...

Star fruit juice is a potent in vitro inhibitor of CYP3A; however, few reports are available on the inhibition of CYP3A activities by star fruit juice in vivo. Therefore, in this study, we investigated the CYP3A-mediated star fruit-drug interaction in vivo. The effect of star fruit juice on carbamazepine pharmacokinetics was examined in rats. In comparison with water, the area under the concent...

The effects of clonazepam (0.3 and 1.0 mg/kg or 0.1 mg/kg, b.i.d., 5 days) and carbamazepine (50 and 100 mg/kg or 12.5 and 50 mg/kg b.i.d., 5 days) on alcohol withdrawal syndrome in rats were investigated. Moreover, the influence of clonazepam (0.3 mg/kg, single dose, or repeated doses for 8 days) and carbamazepine (50 mg/kg, single dose, or repeated doses for 8 days) on the development of tole...