Abstract Neoantigens derived from somatic mutations in cancer cells can induce antigen‐specific T‐cell immune response for immunotherapy. However, the 3D models assessing neoepitope immunogenicity and efficacy of anti‐tumor to neoantigens are less than perfect. Here, a tumor model based on recellularized liver matrix is leveraged with HepG2 investigate T cell cytotoxic reactivity toward hepatoc...

A murine monoclonal antibody (M31-15) was identified using the penetration-inhibiting assay of a human lung adenocarcinoma cell line (MAC10) and remarkably inhibited the phagokinetic tract motility of various cancer cell lines. The antigen, motility-related protein (MRP-1), recognized by M31-15, was 25- and 28-kD proteins, and M31-15 was used to isolate a cDNA clone from a human breast carcinom...

Sir, Squamous cell carcinoma (SCC) can occur anywhere on the skin and in mucous membranes with a squamous epithelium (1). Malignant tumours producing granulocyte colony-stimulating factor (G-CSF) have been reported in lung cancer, thyroid carcinoma, bladder carcinoma and cutaneous angiosarcoma (2). We encountered a case of G-CSF-producing SCC, which was diagnosed by immunohistochemical staining...

Background: The role of infectious agents in prostate cancer development has been considered for many years. Polyomaviruses are suspected to be related to human malignancies and they have been frequently detected from various human cancers. Aim: This study was performed to investigate presence of large t antigen encoded by Merkel Cell polyomavirus (MCV), JC polyomavirus (JCV), BK polyomavirus (...

OBJECTIVE Surgical resection is an important form of treatment for pulmonary metastases from colorectal carcinoma. We analyzed the clinical course, outcome, and prognostic factors after surgery. METHODS Between 1985 and 2000, 167 patients (103 men, 64 women) underwent complete pulmonary resection of metastatic colorectal carcinoma. Only patients who met the criteria for potentially curative o...

hbme-l is an antimesothelial monoclonal antibody that recognizes an unknown antigen on microvilli of mesothelial cells. the antibody is only relatively specific for mesothelium and is used in the differential diagnosis of mesothelioma and adenocarcinoma within the context of an appropriate immuno-histochemical panel. hbme-l has also been reported to strongly and uniformly stain papillary and fo...

BACKGROUND ABO blood group and risk of squamous cell carcinoma of esophagus have been reported by many studies, but there is no discipline that had provided association with the genotype and gene frequency by population statics. METHODS We conducted a case-control study on 480 patients with squamous cell carcinoma of the esophagus and 480 noncancer patients. ABO blood group was determined by ...

This study explored the 605 nm carboxyl of water-soluble quantum dots to assess the practicability of the nasopharyngeal carcinoma marker EBNA1 antibody. We used 605 nm carboxyl water-soluble quantum dots and nasopharyngeal carcinoma EBNA1 antigen in 1-(3-dimethylaminopropyl-3-2-ethylcarbonimine hydrochloride to generate quantum dot-labeled antigen. Gel imaging system showed that serum group an...

Serum carcinoembryonic antigen (CEA) levels were obtained before operation in 214 patients undergoing diagnostic tests for suspected bronchial carcinoma, and the results correlated with the postoperative, pathological stage of disease. Positive CEA levels (greater than 10 ng/ml) were observed in 40% (8/20) of stage 1, 58.5% (31/53) of stage 2, 85.2% (69/81) of stage 3, and 92.3% (24/26) of stag...