Duchenne muscular dystrophy (DMD) is a degenerative disorder affecting skeletal and cardiac muscle for which there is no effective therapy. Angiotension receptor blockade (ARB) has excellent therapeutic potential in DMD based on recent data demonstrating attenuation of skeletal muscle disease progression during 6-9 months of therapy in the mdx mouse model of DMD. Since cardiac-related death is ...

The cardiac ryanodine receptor (RyR2) is inhibited by calmodulin (CaM) and S100A1. Simultaneous substitution of three amino acid residues (W3587A, L3591D, F3603A; RyR2ADA) in the CaM binding domain of RyR2 results in loss of CaM inhibition at submicromolar (diastolic) and micromolar (systolic) Ca²⁺, cardiac hypertrophy, and heart failure in Ryr2ADA/ADA mice. To address whether cardiac hypertrop...

Background Elevated high sensitivity cardiac troponin (cTnT) levels, LVEF, and the degree of myocardial replacement fibrosis (RF) have been shown to be significantly associated with cardiovascular outcomes. However, the relationship amongst them has yet to be studied. Cardiac magnetic resonance (CMR) has become the gold standard for viability imaging and accurately characterizing RF. Recently, ...

Objectives: To elucidate the role of KLF15 on cardiac fibroblast in the dynamic angiogenesis in pressureoverload cardiac remodeling. Methods: Aortic banding was performed in rats to induce pressure-overload and cardiac hypertrophy. Part of the animals has their aorta constriction removed 3 or 6 weeks after the banding surgery. Cardiac function by echocardiography, cardiac tissue morphology and ...

There is a spectrum of cardiac malformations known as “ Cono Truncal Anomalies “ which refl ect an abnormal transfer during development of the aorta from the right to the left ventricle. R H Anderson proposed a system of nomenclature and classifi cation of Congenital Heart Disease totally descriptive with sequential-segmental analysis according to the sequential approach of R.Van Praagh [1-2]. ...

MR examination of patients with congenital heart disease is a useful means of explicitly demonstrating chamber morphology and, in particular, morphologic changes caused by physiologic changes brought on by particular defects. Use of MR techniques allows characterization of chamber morphology for determination of cardiac connections and great artery relationships. The high-contrast resolution of...

Background Single ventricle (SV) physiology consists of a single pumping chamber that provides both systemic and pulmonary blood flow. The typical quantitative measurements of ventricular function (i.e. ejection fraction) cannot be accurately applied to single ventricles due to abnormal ventricular morphology. Cardiac Magnetic Resonance (CMR) has become a leading diagnostic tool in the assessme...

Objective: Cardiac sarcoidosis (CS) can manifest with different clinical signs and has a poor prognosis, but the heart is rarely affected alone. We aim to evaluate arrhythmogenic effects of by using electrocardiography (ECG) in patients or without cardiac involvement. Materials Methods: A total 61 under follow-up for pulmonary were retrospectively reviewed 50 healthy volunteers enrolled study. ...

1. Graff C, Toft E, Matz J, Kanters JK, AndersenMP, Nielsen J, Struijk JJ. Covariate analysis of T-wave morphology and QTc prolongation: Newinsights into drug-induced ECG changes.WorldPharma, Copenhagen, Denmark (2010)2. Graff C, Toft E, Matz J, Kanters JK, AndersenMP, Nielsen J, Struijk JJ. Covariate assessment ofT-wave morphology and QTc prolongation: Newopport...

BACKGROUND Periprocedural myocardial infarction (PMI) may occur in approximately 5% to 30% of patients undergoing percutaneous coronary intervention. Whether the morphology of coronary plaque calcium affects the occurrence of PMI is unknown. MATERIALS AND METHODS A total of 616 subjects with stable angina and normal baseline cardiac troponin I levels who had undergone computed tomography angi...