Mitochondria play a pivotal role in cardioprotection. Here we report some fundamental studies which considered the role of mitochondrial components (connexin 43, mitochondrial KATP channels and mitochondrial permeability transition pore) in postconditioning cardioprotection. We briefly discuss the role of mitochondria, reactive oxygen species and gaseous molecules in postconditioning. Also the ...

Abstract Background HDL dysfunction rather than HDL-cholesterol concentration is involved in the pathogenesis of coronary artery disease (CAD) and type-2 diabetes (T2DM). While causes consequences are manifold, reduced concentrations HDL-sphingosine-1-phsophate (S1P) partially responsible for impaired vasodilation suppression inflammation by CAD-HDL. Administration healthy human prior to ischem...

Using two-dimensional electrophoresis, mass spectrometry, immunoblotting, and affinity pull-down assays, we found that myocardial protein kinase C epsilon (PKCepsilon) is physically associated with at least 36 known proteins that are organized into structural proteins, signaling molecules, and stress-responsive proteins. Furthermore, we found that the cardioprotection induced by activation of P...

Acute coronary syndrome (ACS) in patients with diabetes continues to present clinical management challenges despite recent improvements in the management of ACS. The diabetic myocardium is more vulnerable to ischemia–reperfusion injury than non-diabetic myocardium and the diabetic patient more likely to develop complications, significant morbidity and death following ACS. Currently, ACS managem...

Scott K. Powers, Ph.D., Ed.D. Professor Department of Exercise and Sport Sciences and Department of Physiology University of Florida Gainesville, Florida In addition to the cardioprotective effects of regular exercise, there is also a growing interest in nutritional antioxidant supplementation as a strategy to protect the heart during a heart attack. Indeed, the role that dietary antioxidants p...

As mediators of the first enzymatic step in glucose metabolism, hexokinases (HKs) orchestrate a variety of catabolic and anabolic uses of glucose, regulate antioxidant power by generating NADPH for glutathione reduction, and modulate cell death processes by directly interacting with the voltage-dependent anion channel (VDAC), a regulatory component of the mitochondrial permeability transition p...

With an increase in the elderly population and an increase in the prevalence of age-related cardiovascular disease, anesthesiologists are increasingly being faced with elderly patients with known or suspected ischemic heart disease in the perioperative period. Although early reperfusion remains the best strategy to reduce ischemic injury, reperfusion may damage the myocardium. Adjuvant therapy ...

The prevalence of the cardiovascular disease significantly affects the outcome of both cardiac and non-cardiac surgery, and perioperative cardiac morbidity is one of the leading causes of death following anesthesia and surgery. The considerable incidence of myocardial infarction, congestive heart failure, myocardial ischemia, or serious dysrhythmias during the intraoperative or postoperative pe...

Overexpression studies have revealed a role for silent information regulator of transcription 1 (SIRT1) lysine deacetylase in cardioprotection against ischemia-reperfusion injury via long-term transcriptional effects. However, short-term SIRT1-mediated lysine deacetylation, within the context of acute cardioprotection, is poorly understood. In this study, the role of SIRT1 in the acute cardiopr...