Chimeric antigen receptors (CAR) and bispecific antibodies (BsAb) are two powerful immunotherapy approaches for retargeting lymphocytes toward cancer cells. Despite their success in lymphoblastic leukemia, solid tumors have been more recalcitrant. Identifying therapeutic barriers facing CAR-modified (CART) or BsAb-redirected T (BsAb-T) cells should facilitate their clinical translation to solid...

Synaptic transmission from Drosophila photoreceptors to lamina neurons requires recycling of histamine neurotransmitter. Synaptic histamine is cleared by uptake into glia and conversion into carcinine, which functions as transport metabolite. How carcinine is transported from glia to photoreceptor neurons remains unclear. In a targeted RNAi screen for genes involved in this pathway, we identifi...

Cocaine and amphetamine regulated transcript (CART) encodes a novel brain-enriched protein whose features are reminiscent of a neurotransmitter propeptide. We have now localized CART peptide(s) in the gastrointestinal tract by immunohistochemical methods. Polyclonal antisera raised to CART peptide 106-129 stained neuronal cell bodies and fibers in rat ileum myenteric plexus-longitudinal muscle ...

This paper relates to the construction and testing of a solarpowered golf cart and the future incorporation of a fuel cell system to the existing solar cart. The prototype built in 2004 [fig 1] proved to be very successful. The combination of unique features such as the tracking of the sun resulted in the increase of output power with respect to other solar carts. In addition, the cart turns in...

CART peptides are endogenous neurotransmitters that are involved in a variety of physiologic functions. Injection of CART 55-102 into the nucleus accumbens produces no effect, but when co-administered with cocaine, it reduces the locomotor and rewarding properties of cocaine. In a human study, subjects carrying a missense mutation of the CART gene exhibited increased anxiety and depression. Als...

Cocaine- and amphetamine-regulated transcript (CART) is a recently discovered hypothalamic peptide regulated by leptin and with a potent appetite-suppressing activity. In the rat, the CART gene encodes a peptide of 116 amino acid residues (or a splice variant 13 residues longer). The predicted signal sequence is 27 amino acid residues, resulting in a prohormone of 89 residues. The CART prohormo...

The advent of combined antiretroviral therapy (cART) resulted in a profound decrease in mortality rates in people infected with the human immunodeficiency virus (HIV). cART greatly extends the lifespan of HIV-infected individuals by reducing viral load, preserving immune function and decreasing the risk of lethal opportunistic infections. With the introduction of cART, HIV infection evolved fro...

The objective of this study is to examine all aspects of fraud triangle using the data mining techniques and employ the available and public information to proxy variables to evaluate such attributes as pressure/incentive, opportunity, and attitude/rationalization, based on the findings from prior studies in this subject field and also the Statement on Auditing Standards. The second objective i...

OBJECTIVE To determine admissions diagnosis and outcomes of HIV-infected patients attending AMPATH ambulatory HIV-care clinics. DESIGN Prospective cohort study. SETTING Academic Model for Prevention and Treatment of HIV/ AIDS (AMPATH) ambulatory HIV-care clinic in western Kenya. RESULTS Between January 2005 and December 2006, 495 HIV-infected patients enrolled in AMPATH were admitted. Med...