A series of novel 5-substituted 2-(arylmethylthio)-4-chloro-N-(5-aryl-1,2,4-triazin-3-yl) benzenesulfonamide derivatives 27-60 have been synthesized by the reaction of aminoguanidines with an appropriate phenylglyoxal hydrate in glacial acetic acid. A majority of the compounds showed cytotoxic activity toward the human cancer cell lines HCT-116, HeLa and MCF-7, with IC50 values below 100 μM. It...

self etching primers, due to ease of manipulation, have been extensively used in recent years. these self etching primers containing a relatively weak acid, may not provide an optimal bond strength. the purpose of the present in-vitro investigation was to evaluate the effects of 37% phosphoric acid application prior to applying self etching primers on composite bond strength. in this experiment...

background: the c1019t polymorphism of the connexin-37 (gja4) gene is a single-nucleotide polymorphisms involved in atherosclerotic plaque rupture and atherosclerosis predisposition. we examined the association between the c1019t polymorphism of the gja4 gene and the occurrence of myocardial infarction (mi) in patients with premature coronary artery disease (cad). methods: our study recruited 1...