The incidence of hepatomas was markedly increased in goldthioglucose-obese CBA males as compared with nonobese controls. Goldthioglucose-induced obesity did not have as striking an effect on the incidence of liver tumors in females when compared with the males, even though the females weighed more than the treated males. Hepatomas appearing in obese intact females and castrated obese and contro...

A methanol extract of banana peel (BPEx, 200 mg/kg, p.o.) significantly suppressed the regrowth of ventral prostates and seminal vesicles induced by testosterone in castrated mice. Further studies in the androgen-responsive LNCaP human prostate cancer cell line showed that BPEx inhibited dose-dependently testosterone-induced cell growth, while the inhibitory activities of BPEx did not appear ag...

It has been stated that the male mouse retains both the Whitten effect (control of the oestrous cycle) and the Bruce effect (control of implantation) to some extent after castration (Bruce, 1959, 1960; Parkes & Bruce, 1961). Subsequent observations failed to confirm either of these early claims. Further experiments on the relation between the gonads and pheromones have now been completed. The m...

Trigonella foenum (TF) has long been used in the traditional Indian systems of medicine for the treatment of various ailments. The objective was to study the anabolic and androgenic activity of the furostanol glycosides fraction of Trigonella foenum-graecum (Fenu-FG) in immature castrated male Wistar rats. It was also aimed to investigate the effect of Fenu-FG on testicular histology in non-cas...

We previously reported that ovine and porcine luteinizing hormone (LH) stimulated kidney growth in castrated hypophysectomized rats. Our present study focuses on the physiological role of the renotropic activity of LH isoforms. Plasma LH levels were decreased to 10% of that of castrated control rats by injections of a slow-releasing LHRH agonist, leuprolide acetate, from microcapsules. Compared...

The present study was designed to evaluate the effects of synthetic ACTH (1-24, tetracosactid) and porcine CRH on the plasma levels of cortisol and PGF2alpha metabolite in cycling gilts (n = 3) and castrated boars (n = 3). The experiments were designed as crossover studies for each gender separately. Each animal received, during three consecutive days; 1) ACTH (Synacthen Depot) at a dose of 10 ...

The present study was designed to evaluate the differences in the coronary vasodilator actions of serotonin (5-HT) in isolated heart obtained from naive or castrated male and female rats that were treated with either estrogen or testosterone. Hearts from 12 groups of rats were used: male and female naive animals, castrated, castrated and treated with 17beta-estradiol (0.5 microg kg(-1) day(-1))...

Iberian x Duroc pigs (n = 168), with an average age of 152 d and 42 +/- 2 kg, were used to investigate the effect of feeding regimen [ad libitum access to feed (AL) vs. 82% of AL from 152 to 201 d of age and 72% from 202 to 263 d of age (FR)] and sex (intact females, castrated females, and castrated males) on growth performance and carcass and meat quality. For the last 54 d before slaughter at...

The antiproliferative effects of an antagonist of growth hormone-releasing hormone (GHRH) JV-1-38 were evaluated in nude mice bearing s.c. xenografts of LNCaP and MDA-PCa-2b human androgen-sensitive and DU-145 androgen-independent prostate cancers. In the androgen-sensitive models, JV-1-38 greatly potentiated the antitumor effect of androgen deprivation induced by surgical castration, but was i...

Adipose tissue was obtained from male, female and male pigs castrated either at birth, 2 or 4 mo of age. Pigs were biopsied at 11 and 20 wk of age to obtain adipose tissue samples. Lipogenic capacity was assessed by measurement of in vitro glucose incorporation into lipids of adipose tissue slices. At 20 wk of age, males were less fat than females or males castrated either at birth or 20 mo of ...